| pubmed-article:1128553 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1128553 | lifeskim:mentions | umls-concept:C0032961 | lld:lifeskim |
| pubmed-article:1128553 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:1128553 | lifeskim:mentions | umls-concept:C0019904 | lld:lifeskim |
| pubmed-article:1128553 | lifeskim:mentions | umls-concept:C0005283 | lld:lifeskim |
| pubmed-article:1128553 | lifeskim:mentions | umls-concept:C0033053 | lld:lifeskim |
| pubmed-article:1128553 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:1128553 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:1128553 | pubmed:dateCreated | 1975-7-14 | lld:pubmed |
| pubmed-article:1128553 | pubmed:abstractText | A Sicilian couple whose first child had homozygous beta-+-thalassemia requiring monthly transfusion requested prenatal diagnosis during the second pregnancy. Fully informed consent was obtained. The placenta was localized by ultra-sound at the 20th week of gestation, and was aspirated with a 20-gauge needle. Samples containing fetal red cells were obtained, and studies of globinchain synthesis showed a normal beta/gamma synthesis ratio for this gestational age. The conclusion that the child was not affected by beta-thalassemia was confirmed when an infant not affected with homozygous of heterozygous beta-thalassemia was born at term. Although more experience with this approach is necessary, this study demonstrates that prenatal diagnosis or exclusion of beta-thalassemia and sickle-cell anemia is feasible. | lld:pubmed |
| pubmed-article:1128553 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1128553 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1128553 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1128553 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1128553 | pubmed:month | May | lld:pubmed |
| pubmed-article:1128553 | pubmed:issn | 0028-4793 | lld:pubmed |
| pubmed-article:1128553 | pubmed:author | pubmed-author:GolbusM SMS | lld:pubmed |
| pubmed-article:1128553 | pubmed:author | pubmed-author:KleinPP | lld:pubmed |
| pubmed-article:1128553 | pubmed:author | pubmed-author:KanY WYW | lld:pubmed |
| pubmed-article:1128553 | pubmed:author | pubmed-author:DozyA MAM | lld:pubmed |
| pubmed-article:1128553 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1128553 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:1128553 | pubmed:volume | 292 | lld:pubmed |
| pubmed-article:1128553 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1128553 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1128553 | pubmed:pagination | 1096-9 | lld:pubmed |
| pubmed-article:1128553 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1128553 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1128553 | pubmed:articleTitle | Successful application of prenatal diagnosis in a pregnancy at risk for homozygous beta-thalassemia. | lld:pubmed |
| pubmed-article:1128553 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1128553 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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