| pubmed-article:11283242 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11283242 | lifeskim:mentions | umls-concept:C0043157 | lld:lifeskim |
| pubmed-article:11283242 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11283242 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11283242 | lifeskim:mentions | umls-concept:C0023693 | lld:lifeskim |
| pubmed-article:11283242 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:11283242 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:11283242 | lifeskim:mentions | umls-concept:C0220938 | lld:lifeskim |
| pubmed-article:11283242 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:11283242 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:11283242 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11283242 | pubmed:dateCreated | 2001-4-3 | lld:pubmed |
| pubmed-article:11283242 | pubmed:abstractText | To understand the role of white collar-2 in the Neurospora circadian clock, we examined alleles of wc-2 thought to encode partially functional proteins. We found that wc-2 allele ER24 contained a conservative mutation in the zinc finger. This mutation results in reduced levels of circadian rhythm-critical clock gene products, frq mRNA and FRQ protein, and in a lengthened period of the circadian clock. In addition, this mutation altered a second canonical property of the clock, temperature compensation: as temperature increased, period length decreased substantially. This temperature compensation defect correlated with a temperature-dependent increase in overall FRQ protein levels, with the relative increase being greater in wc-2 (ER24) than in wild type, while overall frq mRNA levels were largely unaltered by temperature. We suggest that this temperature-dependent increase in FRQ levels partially rescues the lowered levels of FRQ resulting from the wc-2 (ER24) defect, yielding a shorter period at higher temperatures. Thus, normal activity of the essential clock component WC-2, a positive regulator of frq, is critical for establishing period length and temperature compensation in this circadian system. | lld:pubmed |
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| pubmed-article:11283242 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11283242 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11283242 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11283242 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11283242 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11283242 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11283242 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:11283242 | pubmed:author | pubmed-author:DunlapJ CJC | lld:pubmed |
| pubmed-article:11283242 | pubmed:author | pubmed-author:LorosJ JJJ | lld:pubmed |
| pubmed-article:11283242 | pubmed:author | pubmed-author:CollettM AMA | lld:pubmed |
| pubmed-article:11283242 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11283242 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:11283242 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11283242 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11283242 | pubmed:pagination | 2619-28 | lld:pubmed |
| pubmed-article:11283242 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11283242 | pubmed:meshHeading | pubmed-meshheading:11283242... | lld:pubmed |
