pubmed-article:11277264 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11277264 | lifeskim:mentions | umls-concept:C0029418 | lld:lifeskim |
pubmed-article:11277264 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
pubmed-article:11277264 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
pubmed-article:11277264 | lifeskim:mentions | umls-concept:C0006631 | lld:lifeskim |
pubmed-article:11277264 | lifeskim:mentions | umls-concept:C1564904 | lld:lifeskim |
pubmed-article:11277264 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
pubmed-article:11277264 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:11277264 | pubmed:dateCreated | 2001-3-29 | lld:pubmed |
pubmed-article:11277264 | pubmed:abstractText | As transmembrane, Ca2+-dependent cell-cell adhesion molecules, cadherins play a central role in tissue morphogenesis and homeostasis. Stable adhesion is dependent on interactions of the cytoplasmic domain of the cadherins with a group of intracellular proteins, the catenins. In the present study, we have detected the expression of alpha-, beta-, and gamma-catenins in human osteoblasts, which assemble with cadherins to form two distinct complexes containing cadherin and alpha-catenin, with either beta- or gamma-catenin. In osteoblasts undergoing apoptosis, proteolytic cleavage of N-cadherin and beta- and gamma- catenins but not alpha-catenin was associated with the activation of caspase-3 and prevented by the caspase inhibitor Z-VAD-fmk. The pattern of cadherin/catenin cleavage detected in apoptotic osteoblasts was reproduced in vitro by recombinant caspase-3. The presence of a 90-kDa extracellular domain fragment of N-cadherin in conditioned medium from apoptotic cells indicates that additional extracellular or membrane-associated proteases also are activated. Disruption of N-cadherin-mediated cell-cell adhesion with function-blocking antibodies induced osteoblast apoptosis, activation of caspases, and cleavage of beta-catenin. These findings provide compelling evidence that N-cadherin-mediated cell-cell adhesion promotes osteoblast survival and suggest that the underlying mechanism may involve activation of beta-catenin signaling. | lld:pubmed |
pubmed-article:11277264 | pubmed:language | eng | lld:pubmed |
pubmed-article:11277264 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11277264 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11277264 | pubmed:month | Mar | lld:pubmed |
pubmed-article:11277264 | pubmed:issn | 0884-0431 | lld:pubmed |
pubmed-article:11277264 | pubmed:author | pubmed-author:RobinsS PSP | lld:pubmed |
pubmed-article:11277264 | pubmed:author | pubmed-author:HunterII | lld:pubmed |
pubmed-article:11277264 | pubmed:author | pubmed-author:McGregorDD | lld:pubmed |
pubmed-article:11277264 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11277264 | pubmed:volume | 16 | lld:pubmed |
pubmed-article:11277264 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11277264 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11277264 | pubmed:pagination | 466-77 | lld:pubmed |
pubmed-article:11277264 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:11277264 | pubmed:year | 2001 | lld:pubmed |
pubmed-article:11277264 | pubmed:articleTitle | Caspase-dependent cleavage of cadherins and catenins during osteoblast apoptosis. | lld:pubmed |
pubmed-article:11277264 | pubmed:affiliation | Matrix Biochemistry Group, Rowett Research Institute, Aberdeen, Scotland. | lld:pubmed |
pubmed-article:11277264 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11277264 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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