| pubmed-article:11273011 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11273011 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:11273011 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:11273011 | lifeskim:mentions | umls-concept:C0032521 | lld:lifeskim |
| pubmed-article:11273011 | lifeskim:mentions | umls-concept:C0920425 | lld:lifeskim |
| pubmed-article:11273011 | lifeskim:mentions | umls-concept:C0025938 | lld:lifeskim |
| pubmed-article:11273011 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11273011 | pubmed:dateCreated | 2001-3-1 | lld:pubmed |
| pubmed-article:11273011 | pubmed:abstractText | pH-sensitive polymeric micelles of randomly and terminally alkylated N-isopropylacrylamide copolymers were prepared and characterized. Aluminium chloride phthalocyanine (AlClPc), a second generation sensitizer for the photodynamic therapy of cancer, was incorporated in the micelles by dialysis. Their photodynamic activities were evaluated in-vitro against EMT-6 mouse mammary tumour cells and in-vivo against EMT-6 tumours implanted intradermally on each hind thigh of Balb/c mice. pH-sensitive polymeric micelles were found to exhibit greater cytotoxicity in-vitro than control Cremophor EL formulations. In the presence of chloroquine, a weak base that raises the internal pH of acidic organelles, in-vitro experiments demonstrated the importance of endosomalllysosomal acidity for the pH-sensitive polymeric micelles to be fully effective. Biodistribution was assessed by fluorescence of tissue extracts after intravenous injection of 2 micromol kg(-1) AlClPc. The results revealed accumulation of AlClPc polymeric micelles in the liver, spleen and lungs, with a lower tumour uptake than AlClPc Cremophor EL formulations. However, polymeric micelles exhibited similar activity in-vivo to the control Cremophor EL formulations, demonstrating the higher potency of AlClPc polymeric micelles when localized in tumour tissue. It was concluded that polymeric micelles represent a good alternative to Cremophor EL preparations for the vectorization of hydrophobic drugs. | lld:pubmed |
| pubmed-article:11273011 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11273011 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11273011 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11273011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11273011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11273011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11273011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11273011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11273011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11273011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11273011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11273011 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11273011 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11273011 | pubmed:issn | 0022-3573 | lld:pubmed |
| pubmed-article:11273011 | pubmed:author | pubmed-author:TailleferJJ | lld:pubmed |
| pubmed-article:11273011 | pubmed:author | pubmed-author:van LierJ EJE | lld:pubmed |
| pubmed-article:11273011 | pubmed:author | pubmed-author:LerouxJ CJC | lld:pubmed |
| pubmed-article:11273011 | pubmed:author | pubmed-author:LenaertsVV | lld:pubmed |
| pubmed-article:11273011 | pubmed:author | pubmed-author:BrasseurNN | lld:pubmed |
| pubmed-article:11273011 | pubmed:author | pubmed-author:Le GarrecDD | lld:pubmed |
| pubmed-article:11273011 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11273011 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:11273011 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11273011 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11273011 | pubmed:pagination | 155-66 | lld:pubmed |
| pubmed-article:11273011 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:meshHeading | pubmed-meshheading:11273011... | lld:pubmed |
| pubmed-article:11273011 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11273011 | pubmed:articleTitle | In-vitro and in-vivo evaluation of pH-responsive polymeric micelles in a photodynamic cancer therapy model. | lld:pubmed |
| pubmed-article:11273011 | pubmed:affiliation | Faculty of Pharmacy, University of Montreal, Qc, Canada. | lld:pubmed |
| pubmed-article:11273011 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11273011 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11273011 | lld:pubmed |
