| pubmed-article:1126940 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1126940 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:1126940 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:1126940 | lifeskim:mentions | umls-concept:C0032550 | lld:lifeskim |
| pubmed-article:1126940 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:1126940 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:1126940 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1126940 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1126940 | pubmed:dateCreated | 1975-7-24 | lld:pubmed |
| pubmed-article:1126940 | pubmed:abstractText | Poly(8-bromoadenylic acid) (poly(8-BrA)) has been synthesized by polymerization of 8-BrADP with polynucleotide phosphorylase in the presence of oligonucleotide primers. In the absence of oligonucleotides, significant (i.e. more than 1%) polymerization does not occur. Oligo(I) primer was removed selectively from the polymer with ribonuclease T1 to yield the homopolymer, poly(8-BrA). End group analysis, based on quantitative infrared measurement of the (Ip)3I-primed polymer, indicates an average degree of polymerization of about 70 residues. The primed polymers and the homopolymer appear to have similar helical structures, probably double-stranded with mutual hydrogen bonding interaction of BrA residues. Preliminary NMR observations of poly(8-BrA) with a tetrainosinic acid primer at the 5' ends of the polymer chain ((Ip)3I-(8-BrA)n) are consistent with the existence of a rigid helical structure below the melting range of the primed polymer. Above the melting range (81 degrees) the H1' coupling constants of (Ip)3I-(8-BrA)n and of polyadenylic acid (poly(A)) suggest a significantly higher population of C3' endo conformation of ribose residues in the primed polymer than in poly(A) at 81 degrees. | lld:pubmed |
| pubmed-article:1126940 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1126940 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1126940 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1126940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1126940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1126940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1126940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1126940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1126940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1126940 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1126940 | pubmed:month | May | lld:pubmed |
| pubmed-article:1126940 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:1126940 | pubmed:author | pubmed-author:MilesH THT | lld:pubmed |
| pubmed-article:1126940 | pubmed:author | pubmed-author:FrazierJJ | lld:pubmed |
| pubmed-article:1126940 | pubmed:author | pubmed-author:HowardF BFB | lld:pubmed |
| pubmed-article:1126940 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1126940 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:1126940 | pubmed:volume | 250 | lld:pubmed |
| pubmed-article:1126940 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1126940 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1126940 | pubmed:pagination | 3951-9 | lld:pubmed |
| pubmed-article:1126940 | pubmed:dateRevised | 2000-12-18 | lld:pubmed |
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| pubmed-article:1126940 | pubmed:meshHeading | pubmed-meshheading:1126940-... | lld:pubmed |
| pubmed-article:1126940 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1126940 | pubmed:articleTitle | Poly(8-bromoadenylic acid): synthesis and characterization of an all-syn polynucleotide. | lld:pubmed |
| pubmed-article:1126940 | pubmed:publicationType | Journal Article | lld:pubmed |
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