| pubmed-article:11264175 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11264175 | lifeskim:mentions | umls-concept:C1335262 | lld:lifeskim |
| pubmed-article:11264175 | lifeskim:mentions | umls-concept:C1366764 | lld:lifeskim |
| pubmed-article:11264175 | lifeskim:mentions | umls-concept:C1977882 | lld:lifeskim |
| pubmed-article:11264175 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11264175 | pubmed:dateCreated | 2001-3-26 | lld:pubmed |
| pubmed-article:11264175 | pubmed:abstractText | This study demonstrates in both stable and inducible BCR-ABL-expressing hematopoietic cells a down-regulation of the major mammalian DNA repair protein DNA-PKcs by BCR-ABL. Similar results were found in BCR-ABL CD34(+) cells from patients with chronic myelogenous leukemia (CML). DNA-PKcs down-regulation is a proteasome-dependent degradation that requires tyrosine kinase activity and is associated with a marked DNA repair deficiency along with increased sensitivity to ionizing radiation. The conjunction of a major DNA repair deficiency and a resistance to apoptosis, both induced by BCR-ABL, provides a new mechanism to explain how secondary genetic alterations can accumulate in CML, eventually leading to blast crisis. The down-regulation of DNA-PKcs was reversible in CD34(+) CML cells suggesting that this approach might offer a novel and powerful therapeutic strategy in this disease, especially to delay the blast crisis. (Blood. 2001;97:2084-2090) | lld:pubmed |
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| pubmed-article:11264175 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11264175 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11264175 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11264175 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11264175 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11264175 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:DeutschEE | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:EschwegeFF | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:VainchenkerWW | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:BourhisJJ | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:TurhanA GAG | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:MarangoniEE | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:RoweG BGB | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:M'KacherRR | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:VaganaySS | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:DugrayAA | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:AbdulKarimBB | lld:pubmed |
| pubmed-article:11264175 | pubmed:author | pubmed-author:MaggiorellaLL | lld:pubmed |
| pubmed-article:11264175 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11264175 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11264175 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:11264175 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11264175 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11264175 | pubmed:pagination | 2084-90 | lld:pubmed |
| pubmed-article:11264175 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11264175 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11264175 | pubmed:articleTitle | BCR-ABL down-regulates the DNA repair protein DNA-PKcs. | lld:pubmed |
| pubmed-article:11264175 | pubmed:affiliation | UPRES EA 27-10 Radiosensibilité-Radiocarcinogenèse Humaine and METSI, Institut Gustave Roussy, Villejuif, France. | lld:pubmed |
| pubmed-article:11264175 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11264175 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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