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pubmed-article:11262586pubmed:abstractTextThe objective of the present study was to assess intestinal permeability in patients with infection caused by Strongyloides stercoralis. Twenty-six patients (16 women and 10 men), mean age 45.9, with a diagnosis of strongyloidiasis were evaluated. For comparison, 25 healthy volunteers (18 women and 7 men), mean age 44.9, without digestive disorders or intestinal parasites served as normal controls. Intestinal permeability was measured on the basis of urinary radioactivity levels during the 24 h following oral administration of chromium-labeled ethylenediaminetetraacetic acid ((51)Cr-EDTA) expressed as percentage of the ingested dose. The urinary excretion of (51)Cr-EDTA was significantly reduced in patients with strongyloidiasis compared to controls (1.60 +/- 0.74 and 3.10 +/- 1.40, respectively, P = 0.0001). Intestinal permeability is diminished in strongyloidiasis. Abnormalities in mucus secretion and intestinal motility and loss of macromolecules could explain the impaired intestinal permeability.lld:pubmed
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pubmed-article:11262586pubmed:authorpubmed-author:LaudannaA AAAlld:pubmed
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pubmed-article:11262586pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11262586pubmed:year2001lld:pubmed
pubmed-article:11262586pubmed:articleTitleIntestinal permeability in strongyloidiasis.lld:pubmed
pubmed-article:11262586pubmed:affiliationLaboratório de Investigação Médica (LIM 07), Departamento de Gastroenterologia, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil.lld:pubmed
pubmed-article:11262586pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11262586pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed