| pubmed-article:11261590 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C0101389 | lld:lifeskim |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C0100748 | lld:lifeskim |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C0017243 | lld:lifeskim |
| pubmed-article:11261590 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:11261590 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:11261590 | pubmed:dateCreated | 2001-3-22 | lld:pubmed |
| pubmed-article:11261590 | pubmed:abstractText | Activin A is a member of the transforming growth factor-beta superfamily that exerts its diverse biological effects through bindings to activin specific transmembrane serine/threonine kinase receptors. The fibroblast-mediated contraction of a collagen gel is thought to be a model of part of the wound-repair response and tissue contraction. In this study, we found the expression of activin type I receptors (ActR-I and ActR-IB) and type II receptor (ActR-II) on human fetal lung fibroblasts (HFL-1) by RT-PCR and immunocytochemistry. We also examined the effects of activin A on the HFL-1-mediated collagen gel contraction. Activin A stimulated collagen gel contraction in a dose dependent manner and its effect was abolished by an activin-binding protein, follistatin, that specifically suppresses activin A activities. This study demonstrated that ActR-I, ActR-1B and ActR-II are expressed on human fetal lung fibroblast and that activin A regulates fibroblast-mediated collagen gel contraction, suggesting that activin A might contribute to human lung fibroblast activities and structural remodeling observed in pulmonary fibrosis. | lld:pubmed |
| pubmed-article:11261590 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11261590 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11261590 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11261590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11261590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11261590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11261590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11261590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11261590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11261590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11261590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11261590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11261590 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11261590 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11261590 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:11261590 | pubmed:author | pubmed-author:TeramotoSS | lld:pubmed |
| pubmed-article:11261590 | pubmed:author | pubmed-author:OrlovV AVA | lld:pubmed |
| pubmed-article:11261590 | pubmed:author | pubmed-author:KägiMM | lld:pubmed |
| pubmed-article:11261590 | pubmed:author | pubmed-author:MatsuseTT | lld:pubmed |
| pubmed-article:11261590 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11261590 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:11261590 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11261590 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11261590 | pubmed:pagination | 1603-13 | lld:pubmed |
| pubmed-article:11261590 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:meshHeading | pubmed-meshheading:11261590... | lld:pubmed |
| pubmed-article:11261590 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11261590 | pubmed:articleTitle | Activin receptors are expressed on human lung fibroblast and activin A facilitates fibroblast-mediated collagen gel contraction. | lld:pubmed |
| pubmed-article:11261590 | pubmed:affiliation | Department of Geriatric Medicine, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:11261590 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11261590 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11261590 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11261590 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11261590 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11261590 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11261590 | lld:pubmed |
