| pubmed-article:11259659 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C1704858 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C2825965 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0536940 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C1413787 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0678836 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0062863 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:11259659 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:11259659 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11259659 | pubmed:dateCreated | 2001-3-29 | lld:pubmed |
| pubmed-article:11259659 | pubmed:abstractText | NY-ESO-1 is a tumor-specific shared antigen with distinctive immunogenicity. Both CD8(+) T cells and class-switched Ab responses have been detected from patients with cancer. In this study, a CD4(+) T cell line was generated from peripheral blood mononuclear cells of a melanoma patient and was shown to recognize NY-ESO-1 peptides presented by HLA-DP4, a dominant MHC class II allele expressed in 43--70% of Caucasians. The ESO p157--170 peptide containing the core region of DP4-restricted T cell epitope was present in a number of tumor cell lines tested and found to be recognized by both CD4(+) T cells as well as HLA-A2-restricted CD8(+) T cells. Thus, the ESO p157--170 epitope represents a potential candidate for cancer vaccines aimed at generating both CD4(+) and CD8(+) T cell responses. More importantly, 16 of 17 melanoma patients who developed Ab against NY-ESO-1 were found to be HLA-DP4-positive. CD4(+) T cells specific for the NY-ESO-1 epitopes were generated from 5 of 6 melanoma patients with NY-ESO-1 Ab. In contrast, no specific DP4-restricted T cells were generated from two patients without detectable NY-ESO-1 Ab. These results suggested that NY-ESO-1-specific DP4-restricted CD4(+) T cells were closely associated with NY-ESO-1 Ab observed in melanoma patients and might play an important role in providing help for activating B cells for NY-ESO-1-specific Ab production. | lld:pubmed |
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| pubmed-article:11259659 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11259659 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11259659 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11259659 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11259659 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11259659 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11259659 | pubmed:author | pubmed-author:RosenbergS... | lld:pubmed |
| pubmed-article:11259659 | pubmed:author | pubmed-author:RobbinsP FPF | lld:pubmed |
| pubmed-article:11259659 | pubmed:author | pubmed-author:WangXX | lld:pubmed |
| pubmed-article:11259659 | pubmed:author | pubmed-author:WangR FRF | lld:pubmed |
| pubmed-article:11259659 | pubmed:author | pubmed-author:ZengGG | lld:pubmed |
| pubmed-article:11259659 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11259659 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:11259659 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11259659 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11259659 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11259659 | pubmed:pagination | 3964-9 | lld:pubmed |
| pubmed-article:11259659 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:11259659 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11259659 | pubmed:articleTitle | CD4(+) T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele: association with NY-ESO-1 antibody production. | lld:pubmed |
| pubmed-article:11259659 | pubmed:affiliation | Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:11259659 | pubmed:publicationType | Journal Article | lld:pubmed |
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