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pubmed-article:11257559pubmed:abstractTextTransplant coronary atherosclerosis is a major limiting factor to successful long-term cardiac transplantation. The depletion of tissue plasminogen activator (tPA) in the arteriolar smooth muscle cells has been associated with a higher incidence of accelerated graft atherosclerosis. In vivo overexpression of tPA may inhibit accelerated graft atherosclerosis and improve the long-term results of heart transplantation. We evaluated the feasibility, distribution, and effects of intracoronary transfer of the human tPA (htPA) gene in a rabbit heterotopic cardiac transplant model, using a novel cationic liposome compound designed for improved delivery to vascular endothelium.lld:pubmed
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pubmed-article:11257559pubmed:articleTitleEffects of human tissue plasminogen gene transfer on allograft coronary atherosclerosis.lld:pubmed
pubmed-article:11257559pubmed:affiliationDivision of Cardiothoracic Surgery, UCLA Medical Center, Los Angeles, California, USA. frank_scholl@hotmail.comlld:pubmed
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