Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:11255262rdf:typepubmed:Citationlld:pubmed
pubmed-article:11255262lifeskim:mentionsumls-concept:C0229671lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C0007595lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1179435lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C0038187lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C0077678lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C0021467lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C0033414lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1420433lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1419428lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1424666lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1415525lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1415887lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1419040lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1419805lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C0598086lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C0598388lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C0004083lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C0021469lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1705248lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1550548lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1555714lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1548799lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1705654lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C1524073lld:lifeskim
pubmed-article:11255262lifeskim:mentionsumls-concept:C0449432lld:lifeskim
pubmed-article:11255262pubmed:issue1lld:pubmed
pubmed-article:11255262pubmed:dateCreated2001-3-20lld:pubmed
pubmed-article:11255262pubmed:abstractTextThe sensitive-to-apoptosis gene (SAG) was initially identified as a redox-inducible, apoptosis-protective protein and subsequently found to be the second family member of regulator of cullins (ROC)/RING box protein (Rbx)/Hrt, which acts as a component of E3 ubiquitin ligase. We report here that SAG promoted cell growth under serum starvation. Microinjection of SAG mRNA into quiescent NIH/3T3 cells induced S-phase entry as determined by [(3)H]-thymidine incorporation. Likewise, overexpression of SAG by either adenovirus infection of immortalized human epidermal keratinocytes (Rhek-1) or DNA transfection of SY5Y human neuroblastoma cells induced cell proliferation under serum starvation. Because cyclin-dependent kinase inhibitors (CKIs), including p21, p27, and p57, are degraded through the ubiquitin pathway, we tested whether SAG-induced cell growth is associated with CKI degradation. Although there was no significant difference in the levels of p21 and p57 between the vector controls and SAG-overexpressing cells, serum starvation induced 10- to 18-fold accumulation of p27 in control Rhek-1 cells. Accumulation of p27 was remarkably inhibited (only 2 to 5-fold) in SAG-infected cells. Inhibition of p27 accumulation was also observed in stably SAG-overexpressing SY5Y cells. Significantly, SAG-associated inhibition of p27 accumulation was largely abolished by the treatment with a proteasome inhibitor. In vivo binding of SAG and Skp2, an F-box protein that promotes p27 ubiquitination, was detected, and the binding was enhanced in SAG-overexpressing cells grown under serum starvation. Thus, SAG-induced growth with serum withdrawal appears to be associated with SAG-mediated p27 degradation. Mol. Carcinog. 30:37-46, 2001.lld:pubmed
pubmed-article:11255262pubmed:languageenglld:pubmed
pubmed-article:11255262pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:citationSubsetIMlld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11255262pubmed:statusMEDLINElld:pubmed
pubmed-article:11255262pubmed:monthJanlld:pubmed
pubmed-article:11255262pubmed:issn0899-1987lld:pubmed
pubmed-article:11255262pubmed:authorpubmed-author:MARSP HPHlld:pubmed
pubmed-article:11255262pubmed:authorpubmed-author:LieIIlld:pubmed
pubmed-article:11255262pubmed:authorpubmed-author:SunYYlld:pubmed
pubmed-article:11255262pubmed:authorpubmed-author:ZhangHHlld:pubmed
pubmed-article:11255262pubmed:authorpubmed-author:SongYYlld:pubmed
pubmed-article:11255262pubmed:authorpubmed-author:SwaroopMMlld:pubmed
pubmed-article:11255262pubmed:authorpubmed-author:WenRRlld:pubmed
pubmed-article:11255262pubmed:authorpubmed-author:DuanHHlld:pubmed
pubmed-article:11255262pubmed:authorpubmed-author:TsvetkovL MLMlld:pubmed
pubmed-article:11255262pubmed:copyrightInfoCopyright 2001 Wiley-Liss, Inc.lld:pubmed
pubmed-article:11255262pubmed:issnTypePrintlld:pubmed
pubmed-article:11255262pubmed:volume30lld:pubmed
pubmed-article:11255262pubmed:ownerNLMlld:pubmed
pubmed-article:11255262pubmed:authorsCompleteYlld:pubmed
pubmed-article:11255262pubmed:pagination37-46lld:pubmed
pubmed-article:11255262pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:meshHeadingpubmed-meshheading:11255262...lld:pubmed
pubmed-article:11255262pubmed:year2001lld:pubmed
pubmed-article:11255262pubmed:articleTitlePromotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation.lld:pubmed
pubmed-article:11255262pubmed:affiliationDepartment of Molecular Biology, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, Michigan 48105, USA.lld:pubmed
pubmed-article:11255262pubmed:publicationTypeJournal Articlelld:pubmed
entrez-gene:6502entrezgene:pubmedpubmed-article:11255262lld:entrezgene
entrez-gene:9616entrezgene:pubmedpubmed-article:11255262lld:entrezgene
entrez-gene:19823entrezgene:pubmedpubmed-article:11255262lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:11255262lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11255262lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11255262lld:pubmed