| pubmed-article:11254623 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C0040561 | lld:lifeskim |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:11254623 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:11254623 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11254623 | pubmed:dateCreated | 2001-3-20 | lld:pubmed |
| pubmed-article:11254623 | pubmed:abstractText | A murine model was used to characterize the local immune and inflammatory response during ocular toxoplasmosis. Major histocompatibility complex (MHC) class I, normally expressed at low levels in immune-privileged sites such as the eye, was up-regulated during infection as determined by competitive reverse transcriptase (RT)-PCR and immunocytochemistry for both beta2-microglobulin and the MHC class I heavy chain. However, the eyes of chronically infected mice also had increased levels of mRNA transcripts for transforming growth factor beta, a cytokine associated with immune privilege and constitutively expressed in normal eyes. Transcripts for a number of inflammatory mediators, including interleukin-6 (IL-6), were increased during chronic infection. The role of IL-6 was further investigated by comparing disease progression and the development of the local immune response in wild-type (WT) and IL-6-deficient mice (IL-6(-/-) mice). Following infection, IL-6(-/-) mice developed more severe inflammation in the retina and vitreous humor compared with WT mice. This increased severity of disease was associated with reduced ocular IL-1alpha and increased tumor necrosis factor alpha mRNA production compared with WT mice. Moreover, the increased severity of disease in IL-6(-/-) mice correlated with increased eye parasite burden as determined by RT-PCR for the Toxoplasma gondii bradyzoite-specific LDH2 gene. These results demonstrate alterations to components of immune privilege as a result of ocular toxoplasmosis and a role for IL-6 in controlling parasite numbers and inflammation in the eye. | lld:pubmed |
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| pubmed-article:11254623 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11254623 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11254623 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11254623 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11254623 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11254623 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:11254623 | pubmed:author | pubmed-author:AlexanderJJ | lld:pubmed |
| pubmed-article:11254623 | pubmed:author | pubmed-author:RobertsFF | lld:pubmed |
| pubmed-article:11254623 | pubmed:author | pubmed-author:FergusonD JDJ | lld:pubmed |
| pubmed-article:11254623 | pubmed:author | pubmed-author:LyonsR ERE | lld:pubmed |
| pubmed-article:11254623 | pubmed:author | pubmed-author:RobertsC WCW | lld:pubmed |
| pubmed-article:11254623 | pubmed:author | pubmed-author:ByrneNN | lld:pubmed |
| pubmed-article:11254623 | pubmed:author | pubmed-author:AnthonyJ PJP | lld:pubmed |
| pubmed-article:11254623 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11254623 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:11254623 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11254623 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11254623 | pubmed:pagination | 2589-95 | lld:pubmed |
| pubmed-article:11254623 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11254623 | pubmed:meshHeading | pubmed-meshheading:11254623... | lld:pubmed |
| pubmed-article:11254623 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11254623 | pubmed:articleTitle | Immunological studies of chronic ocular toxoplasmosis: up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6. | lld:pubmed |
| pubmed-article:11254623 | pubmed:affiliation | Department of Immunology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow, Scotland. | lld:pubmed |
| pubmed-article:11254623 | pubmed:publicationType | Journal Article | lld:pubmed |
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