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pubmed-article:11252350pubmed:dateCreated2001-3-16lld:pubmed
pubmed-article:11252350pubmed:abstractTextIt has been suggested that human endogenous retroviruses K family (HERV-K) has a role in disease, and solitary long terminal repeats (LTRs) of HERV-K have been potentially capable of affecting the expression of closely located genes. Using the human monochromosomes 8, 9, 17, and 18, with specific PCR primers, we identified thirty-four sequences of new HERV-K LTRs. Those LTR elements were analyzed phylogenetically with the human-specific HERV-K LTRs using neighbor-joining and maximum parsimony methods. Clones HKL8-5, HKL9-5, and HKL9-8 are related by more than 99% homology with the human-specific HERV-K LTRs. The HKL9-5 clone on chromosome 9 was 100% identical with the sequences of human-specific LTR, AC002400, on chromosome 16. The findings suggest that there has been recent proliferation, transposition, or chromosomal translocation of HERV-K LTR elements on human chromosomes.lld:pubmed
pubmed-article:11252350pubmed:languageenglld:pubmed
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pubmed-article:11252350pubmed:authorpubmed-author:HyunB HBHlld:pubmed
pubmed-article:11252350pubmed:authorpubmed-author:KimH SHSlld:pubmed
pubmed-article:11252350pubmed:authorpubmed-author:CookP DPDlld:pubmed
pubmed-article:11252350pubmed:authorpubmed-author:LeeW HWHlld:pubmed
pubmed-article:11252350pubmed:authorpubmed-author:JingS LSLlld:pubmed
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pubmed-article:11252350pubmed:pagination121-7lld:pubmed
pubmed-article:11252350pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:11252350pubmed:articleTitleNucleotide sequence and phylogenetic analysis of long terminal repeats of human endogenous retrovirus K family (HERV-K) on human chromosomes.lld:pubmed
pubmed-article:11252350pubmed:affiliationDivision of Biological Sciences, College of Natural Sciences, Pusan National University, Korea. khs307@hyowon.cc.pusan.ac.krlld:pubmed
pubmed-article:11252350pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11252350pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed