| pubmed-article:11246536 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11246536 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11246536 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:11246536 | lifeskim:mentions | umls-concept:C0004057 | lld:lifeskim |
| pubmed-article:11246536 | lifeskim:mentions | umls-concept:C0010068 | lld:lifeskim |
| pubmed-article:11246536 | lifeskim:mentions | umls-concept:C0344315 | lld:lifeskim |
| pubmed-article:11246536 | lifeskim:mentions | umls-concept:C0074554 | lld:lifeskim |
| pubmed-article:11246536 | lifeskim:mentions | umls-concept:C0040018 | lld:lifeskim |
| pubmed-article:11246536 | lifeskim:mentions | umls-concept:C0201950 | lld:lifeskim |
| pubmed-article:11246536 | lifeskim:mentions | umls-concept:C0428466 | lld:lifeskim |
| pubmed-article:11246536 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:11246536 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11246536 | pubmed:dateCreated | 2001-3-14 | lld:pubmed |
| pubmed-article:11246536 | pubmed:abstractText | Aspirin and statins are beneficial in coronary heart disease across a broad range of cholesterol levels. We assessed the effects of low-dose aspirin (75 mg daily) on thrombin generation in patients with coronary heart disease and average blood cholesterol levels. We also investigated whether in patients with borderline-high cholesterol level who have been already taking aspirin, additional treatment with simvastatin would affect thrombin generation. Seven-day treatment with low-dose aspirin decreased thrombin generation ex vivo only in patients with total cholesterol < or = 5.2 mmol/L. In patients with higher cholesterol levels aspirin had no effect. In these patients, already taking low-dose aspirin, additional three-month simvastatin treatment resulted in a reduction of thrombin generation. This demonstrates that low-dose aspirin depresses thrombin generation only in subjects with desirable blood cholesterol levels, while in others, with borderline-high cholesterol, thrombin formation is being reduced following the addition of simvastatin. | lld:pubmed |
| pubmed-article:11246536 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11246536 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11246536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11246536 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11246536 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11246536 | pubmed:issn | 0340-6245 | lld:pubmed |
| pubmed-article:11246536 | pubmed:author | pubmed-author:SzczeklikAA | lld:pubmed |
| pubmed-article:11246536 | pubmed:author | pubmed-author:BrozekJJ | lld:pubmed |
| pubmed-article:11246536 | pubmed:author | pubmed-author:Musia?JJ | lld:pubmed |
| pubmed-article:11246536 | pubmed:author | pubmed-author:UndasAA | lld:pubmed |
| pubmed-article:11246536 | pubmed:author | pubmed-author:UndasRR | lld:pubmed |
| pubmed-article:11246536 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11246536 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:11246536 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11246536 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11246536 | pubmed:pagination | 221-5 | lld:pubmed |
| pubmed-article:11246536 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:11246536 | pubmed:meshHeading | pubmed-meshheading:11246536... | lld:pubmed |
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| pubmed-article:11246536 | pubmed:meshHeading | pubmed-meshheading:11246536... | lld:pubmed |
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| pubmed-article:11246536 | pubmed:meshHeading | pubmed-meshheading:11246536... | lld:pubmed |
| pubmed-article:11246536 | pubmed:meshHeading | pubmed-meshheading:11246536... | lld:pubmed |
| pubmed-article:11246536 | pubmed:meshHeading | pubmed-meshheading:11246536... | lld:pubmed |
| pubmed-article:11246536 | pubmed:meshHeading | pubmed-meshheading:11246536... | lld:pubmed |
| pubmed-article:11246536 | pubmed:meshHeading | pubmed-meshheading:11246536... | lld:pubmed |
| pubmed-article:11246536 | pubmed:meshHeading | pubmed-meshheading:11246536... | lld:pubmed |
| pubmed-article:11246536 | pubmed:meshHeading | pubmed-meshheading:11246536... | lld:pubmed |
| pubmed-article:11246536 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11246536 | pubmed:articleTitle | Treatment with simvastatin and low-dose aspirin depresses thrombin generation in patients with coronary heart disease and borderline-high cholesterol levels. | lld:pubmed |
| pubmed-article:11246536 | pubmed:affiliation | Dept of Medicine, Jagiellonian University School of Medicine, Krakow, Poland. mmmusia@cyf-kr.edu.pl | lld:pubmed |
| pubmed-article:11246536 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11246536 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:11246536 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11246536 | lld:pubmed |
