| pubmed-article:11244613 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11244613 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11244613 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:11244613 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:11244613 | lifeskim:mentions | umls-concept:C0403447 | lld:lifeskim |
| pubmed-article:11244613 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:11244613 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:11244613 | lifeskim:mentions | umls-concept:C0002521 | lld:lifeskim |
| pubmed-article:11244613 | lifeskim:mentions | umls-concept:C0242972 | lld:lifeskim |
| pubmed-article:11244613 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11244613 | lifeskim:mentions | umls-concept:C2348609 | lld:lifeskim |
| pubmed-article:11244613 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:11244613 | pubmed:dateCreated | 2001-3-13 | lld:pubmed |
| pubmed-article:11244613 | pubmed:abstractText | The aim of our study was to evaluate the effect of a low-protein diet supplemented with keto acids-amino acids on renal function and urinary excretion of branched-chain amino acids (BCAA) in patients with chronic renal insufficiency (CRI). In a prospective investigation 28 patients with CRI (16 male, 12 female, aged 28-66 yrs, CCr 18.6 +/- 10.2 ml/min) on a low-protein diet (0.6 g of protein /kg BW/day and energy intake 140 kJ/kg BW/day) for a period of one month were included. Subsequently, this low protein diet was supplemented with keto acids-amino acids at a dose of 0.1 g/kg BW/day orally for a period of 3 months. Examinations performed at baseline and at the end of the follow-up period revealed significant increase in the serum levels of BCAA leucine (p < 0.02), isoleucine (p < 0.03), and valine (p < 0.02) while their renal fractional excretion declined (p < 0.02, p < 0.01 resp.). Keto acid-amino acid administration had no effect on renal function and on the clearance of inulin, para-aminohippuric acid. Endogenous creatinine and urea clearance remained unaltered. A significant correlation between fractional excretion of sodium and leucine (p < 0.05) and a hyperbolic relationship between inulin clearance and fractional excretion of BCAA (p < 0.01) were seen. Moreover, a significant decrease in proteinuria (p < 0.02), plasma urea concentration and renal urea excretion and a rise in albumin level (p < 0.03) were noted. We conclude that in patients with CRI on a low protein diet the supplementation of keto acids-amino acids does not affect renal hemodynamics, but is associated--despite increases in plasma concentrations--with a reduction of renal amino acid and protein excretion suggesting induction of alterations in the tubular transport mechanisms. | lld:pubmed |
| pubmed-article:11244613 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244613 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11244613 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244613 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11244613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244613 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11244613 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11244613 | pubmed:issn | 0043-5325 | lld:pubmed |
| pubmed-article:11244613 | pubmed:author | pubmed-author:HoráckováMM | lld:pubmed |
| pubmed-article:11244613 | pubmed:author | pubmed-author:SchückOO | lld:pubmed |
| pubmed-article:11244613 | pubmed:author | pubmed-author:TeplanVV | lld:pubmed |
| pubmed-article:11244613 | pubmed:author | pubmed-author:SkibováJJ | lld:pubmed |
| pubmed-article:11244613 | pubmed:author | pubmed-author:HolecekMM | lld:pubmed |
| pubmed-article:11244613 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11244613 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:11244613 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:11244613 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11244613 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11244613 | pubmed:pagination | 876-81 | lld:pubmed |
| pubmed-article:11244613 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:meshHeading | pubmed-meshheading:11244613... | lld:pubmed |
| pubmed-article:11244613 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11244613 | pubmed:articleTitle | Effect of a keto acid-amino acid supplement on the metabolism and renal elimination of branched-chain amino acids in patients with chronic renal insufficiency on a low protein diet. | lld:pubmed |
| pubmed-article:11244613 | pubmed:affiliation | Department of Nephrology, Transplant Center, Institute of Clinical and Experimental Medicine, Postgraduate Medical School, Prague, Czech Republic. vladimir.teplan@medicon.cz | lld:pubmed |
| pubmed-article:11244613 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11244613 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:11244613 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11244613 | lld:pubmed |
