| pubmed-article:11244505 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C0018873 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C1415884 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C1538631 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C1825005 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C1332838 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11244505 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11244505 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11244505 | pubmed:dateCreated | 2001-3-13 | lld:pubmed |
| pubmed-article:11244505 | pubmed:abstractText | P22PRG1/IEX-1 is a putative NF-kappaB target gene implicated in the regulation of cellular viability. Here, we show that in HeLa cells TNFalpha induces expression of p22PRG1/IEX-1 in an NF-kappaB dependent fashion. Blockade of NF-kappaB activation by various NF-kappaB inhibitors abolished TNFalpha-induced p22PRG1/IEX-1 expression and increased the sensitivity to apoptosis induced by TNFalpha, an activating Fas-antibody or the anti-cancer drug etoposide. Surprisingly, ectopic expression of p22PRG1/IEX-1 in HeLa cells transfected with an inducible p22PRG1/IEX-1-expression vector augments the susceptibility to apoptosis initiated by death-receptor ligands or by etoposide. In addition, p22PRG1/IEX-1 expressing HeLa cells exhibit an accelerated progression through the cell cycle. Transfection of an antisense hammerhead ribozyme targeted to p22PRG1/IEX-1 reduced the speed in cell cycle progression and decreased the apoptotic response to death ligands. Our data demonstrate that p22PRG1/IEX-1 is specifically induced during NF-kappaB activation, but this seems not to be related to the anti-apoptotic actions of NF-kappaB. Instead, NF-kappaB dependent recruitment of p22PRG1/IEX-1 might be related to a modulation in the cell cycle, and hereby, p22PRG1/IEX-1 may accelerate cell growth on the one hand, but may trigger apoptosis on the other. Oncogene (2001) 20, 69 - 76. | lld:pubmed |
| pubmed-article:11244505 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11244505 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244505 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11244505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11244505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11244505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11244505 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11244505 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11244505 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11244505 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:11244505 | pubmed:author | pubmed-author:FölschU RUR | lld:pubmed |
| pubmed-article:11244505 | pubmed:author | pubmed-author:SchäferHH | lld:pubmed |
| pubmed-article:11244505 | pubmed:author | pubmed-author:SchmidtW EWE | lld:pubmed |
| pubmed-article:11244505 | pubmed:author | pubmed-author:ArltAA | lld:pubmed |
| pubmed-article:11244505 | pubmed:author | pubmed-author:KruseM LML | lld:pubmed |
| pubmed-article:11244505 | pubmed:author | pubmed-author:GrobeOO | lld:pubmed |
| pubmed-article:11244505 | pubmed:author | pubmed-author:SiekeAA | lld:pubmed |
| pubmed-article:11244505 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11244505 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:11244505 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11244505 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11244505 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11244505 | pubmed:pagination | 69-76 | lld:pubmed |
| pubmed-article:11244505 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11244505 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11244505 | pubmed:articleTitle | Expression of the NF-kappa B target gene IEX-1 (p22/PRG1) does not prevent cell death but instead triggers apoptosis in Hela cells. | lld:pubmed |
| pubmed-article:11244505 | pubmed:affiliation | Laboratory of Molecular Gastroenterology, First Department of Medicine, University of Kiel, Schittenhelmstr. 12, D-24105 Kiel, Germany. | lld:pubmed |
| pubmed-article:11244505 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11244505 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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