| pubmed-article:11222774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11222774 | lifeskim:mentions | umls-concept:C0007635 | lld:lifeskim |
| pubmed-article:11222774 | lifeskim:mentions | umls-concept:C1418276 | lld:lifeskim |
| pubmed-article:11222774 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11222774 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11222774 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11222774 | pubmed:dateCreated | 2001-3-6 | lld:pubmed |
| pubmed-article:11222774 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11222774 | pubmed:abstractText | c-Maf is a bZip transcription factor expressed in developmental and cellular differentiation processes. Recently, a c-maf knockout mouse model, showing abnormal lens development, has been reported. In order to study the regulation mechanisms of c-maf gene expression during the differentiation process we have cloned and functionally characterized the rat c-maf (maf-2) gene. The rat c-maf gene is an intronless gene, covering a length of 3.5 kb. Transient transfection analysis of the 5'-flanking region of the c-maf gene using luciferase as the reporter gene shows that Pax6, a master transcription factor for lens development, strongly activates the c-maf promoter construct. Endogenous c-maf is also activated by the Pax6 expression vector. Electrophoresis mobility shift assay and DNase I footprinting analysis show that at least three Pax6-binding sites are located in the 5'-flanking and 5'-non-coding regions of the rat c-maf gene. The c-maf gene was also markedly activated by its own product, c-Maf, through the MARE (Maf recognition element), suggesting that a positive autoregulatory mechanism controls this gene. In situ hybridization histochemical detection of Pax6 and c-Maf in the E14 lens showed that both mRNAs are expressed in the lens equator where lens epithelial cells are differentiating to lens fiber cells. These results suggest that a Pax6/c-Maf transcription factor cascade is working in lens development. | lld:pubmed |
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| pubmed-article:11222774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11222774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11222774 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11222774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11222774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11222774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11222774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11222774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11222774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11222774 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11222774 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:11222774 | pubmed:author | pubmed-author:YoshidaKK | lld:pubmed |
| pubmed-article:11222774 | pubmed:author | pubmed-author:NishiSS | lld:pubmed |
| pubmed-article:11222774 | pubmed:author | pubmed-author:IkedaHH | lld:pubmed |
| pubmed-article:11222774 | pubmed:author | pubmed-author:SakaiMM | lld:pubmed |
| pubmed-article:11222774 | pubmed:author | pubmed-author:ImajoSS | lld:pubmed |
| pubmed-article:11222774 | pubmed:author | pubmed-author:SerriaM SMS | lld:pubmed |
| pubmed-article:11222774 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:11222774 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11222774 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:11222774 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11222774 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11222774 | pubmed:pagination | 1228-37 | lld:pubmed |
| pubmed-article:11222774 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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