| pubmed-article:11222723 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C1511625 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C1749488 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C1422036 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C1947976 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C2346841 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:11222723 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:11222723 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11222723 | pubmed:dateCreated | 2001-3-6 | lld:pubmed |
| pubmed-article:11222723 | pubmed:abstractText | Short amino acid sequences in the cytosolic domains of transmembrane proteins are recognized by specialized adaptor [corrected] proteins which are part of coated vesicles utilized to transport membrane proteins between the trans-Golgi network (TGN) and the plasma membrane (forward and backward). Previously, we and others reported that the membrane-proximal tyrosine residues Y712 (human immunodeficiency virus [HIV]) and Y721 (simian immunodeficiency virus [SIV]) in the envelope glycoprotein (Env) of the primate lentiviruses are crucial for the association of Env with clathrin-associated adaptor [corrected] complex AP-2. The same tyrosine-based endocytosis motifs in the cytosolic domains (EnvCD) of transmembrane gp41 of HIV type 1 (HIV-1) and SIV, respectively, were also shown to modulate the interaction with TGN- and endosome-based clathrin-associated complex AP-1. Our findings suggested that EnvCD binding to AP-1, unlike the association of EnvCD with AP-2, is dependent largely on residues other than Y712 and Y721. Here, we tested if motifs downstream of Y712 affect HIV-1 EnvCD-AP-1 binding and Env trafficking. Mutational analysis revealed that the C-terminal leucine-based motif in Env was crucial for the recruitment of AP-1 in vitro and in Env-expressing cells. In addition to affecting Env-AP-1 association, mutations at the C terminus of Env also altered the subcellular localization of Env, suggesting that proper post-Golgi routing of Env depends on its recruitment of AP-1. Finally, the C-terminal dileucine was shown to assist the membrane-proximal Y712 motif in restricting the cell surface expression of Env. | lld:pubmed |
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| pubmed-article:11222723 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11222723 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11222723 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11222723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11222723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11222723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11222723 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11222723 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11222723 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:11222723 | pubmed:author | pubmed-author:BenarousRR | lld:pubmed |
| pubmed-article:11222723 | pubmed:author | pubmed-author:WyssSS | lld:pubmed |
| pubmed-article:11222723 | pubmed:author | pubmed-author:ThaliMM | lld:pubmed |
| pubmed-article:11222723 | pubmed:author | pubmed-author:BlokNN | lld:pubmed |
| pubmed-article:11222723 | pubmed:author | pubmed-author:HöningSS | lld:pubmed |
| pubmed-article:11222723 | pubmed:author | pubmed-author:Berlioz-Torre... | lld:pubmed |
| pubmed-article:11222723 | pubmed:author | pubmed-author:BogeMM | lld:pubmed |
| pubmed-article:11222723 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11222723 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:11222723 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11222723 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11222723 | pubmed:pagination | 2982-92 | lld:pubmed |
| pubmed-article:11222723 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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