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pubmed-article:11213077pubmed:abstractTextCirculating xanthine oxidase activity and the generated oxidants have been linked to lung reperfusion injury from no flow-reflow conditions in other organs after organ transplantation or surgery. N-acetyl-1-cysteine (NAC), an oxidant scavenger, promotes glutathione in its reduced form (GSH) that is depleted during ischemia. We have recently demonstrated its efficacy in protecting lungs from reperfusion injury if administered during reperfusion of postischemic liver. We now investigated whether preconditioning of lungs with NAC could attenuate lung respiratory or vascular derangement after no flow-reflow (ischemia-reperfusion, IR) and if this depends on lung GSH levels.lld:pubmed
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pubmed-article:11213077pubmed:articleTitleLung preconditioning with N-acetyl-L-cysteine prevents reperfusion injury after liver no flow-reflow: a dose-response study.lld:pubmed
pubmed-article:11213077pubmed:affiliationDepartment of Anesthesiology, Tel Aviv Sourasky Medical Center, Israel. draviw@tasmc.health.gov.illld:pubmed
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