| pubmed-article:11208569 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11208569 | lifeskim:mentions | umls-concept:C1123019 | lld:lifeskim |
| pubmed-article:11208569 | lifeskim:mentions | umls-concept:C0162859 | lld:lifeskim |
| pubmed-article:11208569 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:11208569 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11208569 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:11208569 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:11208569 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:11208569 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11208569 | pubmed:dateCreated | 2001-3-14 | lld:pubmed |
| pubmed-article:11208569 | pubmed:abstractText | Whereas previous studies have established that many mechanisms mediating pharmacomechanical coupling are subject to regulation, evidence of physiological regulation of the coupling efficiency between receptor activation and second-messenger production is scarce. The present studies address the hypothesis that acute hypoxia and maturation can influence the mass of second-messenger production for each activated agonist-bound receptor ("receptor gain"). For this assessment, receptor density and agonist affinity values were used to calculate 5-hydroxytryptamine (5-HT) concentrations that would produce standardized numbers of bound receptors (8.5 fmol/mg protein) in each experimental group and thus minimize effects of age or hypoxia on receptor density or agonist affinity. After 3 min of exposure to these 5-HT concentrations, normoxic magnitudes of contraction were similar (as %potassium maxima) in fetal (50 +/- 14%) and adult (40 +/- 9%) arteries, but hypoxia (PO(2) approximately 9--12 Torr for 30 min) depressed contractile tensions with a significantly different time course and magnitude in fetal (30 +/- 10%) and adult (17 +/- 11%) arteries (P < 0.05). Basal inositol 1,4,5-trisphosphate (IP(3)) values (in pmol/mg protein) were significantly greater in fetal (94 +/- 16) than in adult (44 +/- 6) arteries, and integrated areas above baseline for the IP(3) time courses (in nmol-s/mg protein) were significantly greater in fetal than in adult arteries both in normoxic (14.3 +/- 1.8 vs. 9.1 +/- 1.6) and hypoxic (15.0 +/- 2.1 vs. 8.6 +/- 1.2) conditions (P < 0.05). Hypoxia altered the IP(3) time courses both in the fetus and the adult but had no significant effect on IP(3 )mobilization or receptor gain. These data demonstrate that for the 5-HT(2a) receptor predominant in this preparation, receptor gain can be experimentally determined, is not influenced by acute hypoxia, but is greater in fetal than in adult ovine carotid arteries. | lld:pubmed |
| pubmed-article:11208569 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11208569 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11208569 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11208569 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11208569 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11208569 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11208569 | pubmed:issn | 0363-6119 | lld:pubmed |
| pubmed-article:11208569 | pubmed:author | pubmed-author:WilliamsJJ | lld:pubmed |
| pubmed-article:11208569 | pubmed:author | pubmed-author:PurdyR ERE | lld:pubmed |
| pubmed-article:11208569 | pubmed:author | pubmed-author:PearceW JWJ | lld:pubmed |
| pubmed-article:11208569 | pubmed:author | pubmed-author:ZhangLL | lld:pubmed |
| pubmed-article:11208569 | pubmed:author | pubmed-author:AngelesD MDM | lld:pubmed |
| pubmed-article:11208569 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11208569 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:11208569 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11208569 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11208569 | pubmed:pagination | R410-7 | lld:pubmed |
| pubmed-article:11208569 | pubmed:dateRevised | 2007-7-18 | lld:pubmed |
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| pubmed-article:11208569 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11208569 | pubmed:articleTitle | Effects of maturation and acute hypoxia on receptor-IP(3) coupling in ovine common carotid arteries. | lld:pubmed |
| pubmed-article:11208569 | pubmed:affiliation | Center for Perinatal Biology, Department of Physiology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA. | lld:pubmed |
| pubmed-article:11208569 | pubmed:publicationType | Journal Article | lld:pubmed |
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