Linked Life Data

11207943

Source:http://linkedlifedata.com/resource/pubmed/id/11207943

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pubmed-article:11207943pubmed:abstractTextAgonist-induced endocytosis of somatostatin receptors determines subsequent cellular responsiveness to peptide agonist and influences somatostatin receptor scintigraphy, a technique to image various tumours. We examined the internalization of sst3HSV, an epitope-tagged type 3 somatostatin receptor, in transfected rat neuroendocrine insulinoma cells. Stimulation of these cells with somatostatin induced trafficking of coexpressed enhanced green fluorescence protein/beta-arrestin1 fusion protein and sst3HSV to colocalize in the same endocytic vesicles. Coexpression of a dominant negative mutant of the arrestin fusion protein with the receptor blocked the internalization of sst3HSV. Stimulation with somatostatin also induced the transient translocation of alpha-adaptin, a component of the adaptor protein complex 2, to the plasma membrane. alpha-adaptin and clathrin colocalized with the receptor. By electron microscopy, we observed internalized sst3 in clathrin coated pits, endosomes and at the limiting membrane of multivesicular bodies, a location typical for receptors being recycled. Concordantly, we observed sst3HSV colocalized with Rab11 in a perinuclear compartment which is likely to correspond to the pericentriolar recycling endosome. Thus, agonist-induced endocytosis of sst3 depends on its interaction with beta-arrestin, involves the adaptor protein complex 2 and proceeds via clathrin coated vesicles to the recycling compartment.lld:pubmed
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pubmed-article:11207943pubmed:articleTitleAgonist-mediated endocytosis of rat somatostatin receptor subtype 3 involves beta-arrestin and clathrin coated vesicles.lld:pubmed
pubmed-article:11207943pubmed:affiliationDeutsches Institut für Ernährungsforschung, Abteilung Molekulare Genetik und Universität Potsdam, Arthur-Schuenert-Allee 114-116, D-14558 Potsdam-Rehbrücke, Germany.lld:pubmed
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pubmed-article:11207943pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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