| pubmed-article:11204564 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11204564 | lifeskim:mentions | umls-concept:C0019069 | lld:lifeskim |
| pubmed-article:11204564 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:11204564 | lifeskim:mentions | umls-concept:C1307126 | lld:lifeskim |
| pubmed-article:11204564 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:11204564 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:11204564 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11204564 | pubmed:dateCreated | 2001-2-1 | lld:pubmed |
| pubmed-article:11204564 | pubmed:abstractText | Mice genetically deficient in factor VII (fVIII) are a model of hemophilia A. As a first step to reproduce in this mouse model what occurs over time in hemophilia A patients treated with human fVIII (hfVIII), we have investigated the time course and the characteristics of their immune response to hfVIII, after multiple intravenous injections. Anti-hfVIII antibodies appeared after four to five injections. They were IgG1 and to a lesser extent IgG2, indicating that they were induced by both Th2 and Th1 cells. Inhibitors appeared after six injections. CD4+ enriched splenocytes from hfVIII-treated mice proliferated in response to fVIII and secreted IL-10: in a few mice they secreted also IFN-gamma and in one mouse IL-4, but never IL-2. A hfVIII-specific T cell line derived from hfVIII-treated mice secreted both IL-4 and IFN-gamma, suggesting that it included both Th1 and Th2 cells. CD4+ enriched splenocytes of hfIII-treated mice recognized all hfVIII domains. Thus, hemophilic mice develop an immune response to hfVIII administered intravenously similar to that of hemophilia A patients. Their anti-hfVIII antibodies can be inhibitors and belong to IgG subclasses homologous to those of inhibitors in hemophilic patients; their anti-hfVIII CD4+ cells recognize a complex repertoire and both Th1 and Th2 cytokines, and especially IL-10, may drive the antibody synthesis. | lld:pubmed |
| pubmed-article:11204564 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11204564 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11204564 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11204564 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11204564 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11204564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11204564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11204564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11204564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11204564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11204564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11204564 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11204564 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11204564 | pubmed:issn | 0340-6245 | lld:pubmed |
| pubmed-article:11204564 | pubmed:author | pubmed-author:HoyerL WLW | lld:pubmed |
| pubmed-article:11204564 | pubmed:author | pubmed-author:ShawM WMW | lld:pubmed |
| pubmed-article:11204564 | pubmed:author | pubmed-author:ParkerEE | lld:pubmed |
| pubmed-article:11204564 | pubmed:author | pubmed-author:RedingMM | lld:pubmed |
| pubmed-article:11204564 | pubmed:author | pubmed-author:LollarPP | lld:pubmed |
| pubmed-article:11204564 | pubmed:author | pubmed-author:WuHH | lld:pubmed |
| pubmed-article:11204564 | pubmed:author | pubmed-author:Conti-FineB... | lld:pubmed |
| pubmed-article:11204564 | pubmed:author | pubmed-author:OkitaD KDK | lld:pubmed |
| pubmed-article:11204564 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11204564 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:11204564 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11204564 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11204564 | pubmed:pagination | 125-33 | lld:pubmed |
| pubmed-article:11204564 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:meshHeading | pubmed-meshheading:11204564... | lld:pubmed |
| pubmed-article:11204564 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11204564 | pubmed:articleTitle | Mechanism of the immune response to human factor VIII in murine hemophilia A. | lld:pubmed |
| pubmed-article:11204564 | pubmed:affiliation | Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis-St Paul, 55108, USA. | lld:pubmed |
| pubmed-article:11204564 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11204564 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11204564 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11204564 | lld:pubmed |
