| pubmed-article:11202360 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11202360 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:11202360 | lifeskim:mentions | umls-concept:C0008809 | lld:lifeskim |
| pubmed-article:11202360 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:11202360 | lifeskim:mentions | umls-concept:C0162621 | lld:lifeskim |
| pubmed-article:11202360 | lifeskim:mentions | umls-concept:C0596802 | lld:lifeskim |
| pubmed-article:11202360 | lifeskim:mentions | umls-concept:C0037633 | lld:lifeskim |
| pubmed-article:11202360 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:11202360 | lifeskim:mentions | umls-concept:C1382100 | lld:lifeskim |
| pubmed-article:11202360 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:11202360 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11202360 | pubmed:dateCreated | 2001-2-1 | lld:pubmed |
| pubmed-article:11202360 | pubmed:abstractText | A fluorescence titration method was applied for the determination of pKa of ciprofloxacin (CPX) in solution. Values of 6.18 +/- 0.05 and 8.76 +/- 0.03 were obtained for pKa1 and pKa2, respectively. The method was used to determine the ionization constants in the presence of liposomes of dipalmitoylphosphatidylcholine (DPPC) and DPPC with 10 mol% of dipalmitoylphosphatidylglycerol. A dependence on the surface charge of liposomes was found which supported the existence of a basic electrostatic interaction between CPX and the phospholipid bilayer. Both pK values for the N-4 butyl-piperazinyl derivative (BCPX) of the parent compound were also determined in solution and in the presence of liposomes. The competition of both drugs for the same binding site as 1-anilino-8-naphtalene sulfonate demonstrate that the interaction is governed by electrostatic forces. | lld:pubmed |
| pubmed-article:11202360 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11202360 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11202360 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11202360 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11202360 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11202360 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11202360 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11202360 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11202360 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11202360 | pubmed:issn | 0031-8655 | lld:pubmed |
| pubmed-article:11202360 | pubmed:author | pubmed-author:VázquezJ LJL | lld:pubmed |
| pubmed-article:11202360 | pubmed:author | pubmed-author:ViñasMM | lld:pubmed |
| pubmed-article:11202360 | pubmed:author | pubmed-author:MerinoSS | lld:pubmed |
| pubmed-article:11202360 | pubmed:author | pubmed-author:MonteroM TMT | lld:pubmed |
| pubmed-article:11202360 | pubmed:author | pubmed-author:Hernández-Bor... | lld:pubmed |
| pubmed-article:11202360 | pubmed:author | pubmed-author:BerlangaMM | lld:pubmed |
| pubmed-article:11202360 | pubmed:author | pubmed-author:DomènechOO | lld:pubmed |
| pubmed-article:11202360 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11202360 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:11202360 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11202360 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11202360 | pubmed:pagination | 14-9 | lld:pubmed |
| pubmed-article:11202360 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:11202360 | pubmed:meshHeading | pubmed-meshheading:11202360... | lld:pubmed |
| pubmed-article:11202360 | pubmed:meshHeading | pubmed-meshheading:11202360... | lld:pubmed |
| pubmed-article:11202360 | pubmed:meshHeading | pubmed-meshheading:11202360... | lld:pubmed |
| pubmed-article:11202360 | pubmed:meshHeading | pubmed-meshheading:11202360... | lld:pubmed |
| pubmed-article:11202360 | pubmed:meshHeading | pubmed-meshheading:11202360... | lld:pubmed |
| pubmed-article:11202360 | pubmed:meshHeading | pubmed-meshheading:11202360... | lld:pubmed |
| pubmed-article:11202360 | pubmed:meshHeading | pubmed-meshheading:11202360... | lld:pubmed |
| pubmed-article:11202360 | pubmed:meshHeading | pubmed-meshheading:11202360... | lld:pubmed |
| pubmed-article:11202360 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11202360 | pubmed:articleTitle | Determination by fluorimetric titration of the ionization constants of ciprofloxacin in solution and in the presence of liposomes. | lld:pubmed |
| pubmed-article:11202360 | pubmed:affiliation | Laboratori V de Fisicoquímica, Facultat de Farmàcia, Barcelona, Spain. | lld:pubmed |
| pubmed-article:11202360 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11202360 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
