| pubmed-article:11181423 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C0205042 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C0288250 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:11181423 | lifeskim:mentions | umls-concept:C0253216 | lld:lifeskim |
| pubmed-article:11181423 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11181423 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11181423 | pubmed:abstractText | 1. Effects of NS-1619, an opener of large conductance Ca2+-activated K+ (BK) channel, on intracellular Ca2+ concentration ([Ca2+]i) and membrane potential were examined in single myocytes freshly isolated from porcine coronary artery. 2. Under current clamp mode, the application of 1-30 microM NS-1619 hyperpolarized the membrane in concentration-dependent manner. The NS-1619-induced hyperpolarization was abolished by the presence of 100 nM iberiotoxin. 3. Application of 1-10 microM NS-1619 hyperpolarized the membrane by approximately 6 mV or less but did not change significantly the [Ca2+]i. When membrane hyperpolarization of 12 mV or so was caused by 30 microM NS-1619, [Ca2+]i was unexpectedly increased by approximately 200 nM. This increase in [Ca2+]i and the concomitant outward current activation were also observed under voltage-clamp at holding potential of -40 mV. 4. The increase in [Ca2+]i by 30 microM NS-1619 occurred mainly in peripheral regions than in the centre of the myocytes. The removal of extracellular Ca2+ affected neither the membrane hyperpolarization nor the increase in [Ca2+]i. 5. In the presence of 10 mM caffeine and 10 microM ryanodine, the increase in [Ca2+]i by 30 microM NS-1619 was not observed and the membrane hyperpolarization was reduced to approximately 67% of the control. 6. These results indicate that the opening of BK channels by NS-1619 at 30 microM, which is the most frequently used concentration of this agent, is partly due to Ca2+ release from caffeine/ryanodine-sensitive intracellular storage sites but is mainly due to the direct activation of the channels. | lld:pubmed |
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| pubmed-article:11181423 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11181423 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11181423 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11181423 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11181423 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11181423 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11181423 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:11181423 | pubmed:author | pubmed-author:WatanabeMM | lld:pubmed |
| pubmed-article:11181423 | pubmed:author | pubmed-author:YamamuraHH | lld:pubmed |
| pubmed-article:11181423 | pubmed:author | pubmed-author:SAT STS | lld:pubmed |
| pubmed-article:11181423 | pubmed:author | pubmed-author:ImaizumiYY | lld:pubmed |
| pubmed-article:11181423 | pubmed:author | pubmed-author:MurakiKK | lld:pubmed |
| pubmed-article:11181423 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11181423 | pubmed:volume | 132 | lld:pubmed |
| pubmed-article:11181423 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11181423 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11181423 | pubmed:pagination | 828-34 | lld:pubmed |
| pubmed-article:11181423 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11181423 | pubmed:meshHeading | pubmed-meshheading:11181423... | lld:pubmed |
| pubmed-article:11181423 | pubmed:meshHeading | pubmed-meshheading:11181423... | lld:pubmed |
| pubmed-article:11181423 | pubmed:meshHeading | pubmed-meshheading:11181423... | lld:pubmed |
| pubmed-article:11181423 | pubmed:meshHeading | pubmed-meshheading:11181423... | lld:pubmed |
| pubmed-article:11181423 | pubmed:meshHeading | pubmed-meshheading:11181423... | lld:pubmed |
| pubmed-article:11181423 | pubmed:meshHeading | pubmed-meshheading:11181423... | lld:pubmed |
| pubmed-article:11181423 | pubmed:meshHeading | pubmed-meshheading:11181423... | lld:pubmed |
| pubmed-article:11181423 | pubmed:meshHeading | pubmed-meshheading:11181423... | lld:pubmed |
| pubmed-article:11181423 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11181423 | pubmed:articleTitle | BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery. | lld:pubmed |
| pubmed-article:11181423 | pubmed:affiliation | Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan. | lld:pubmed |
| pubmed-article:11181423 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11181423 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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