| pubmed-article:11180000 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11180000 | lifeskim:mentions | umls-concept:C0376387 | lld:lifeskim |
| pubmed-article:11180000 | lifeskim:mentions | umls-concept:C0029216 | lld:lifeskim |
| pubmed-article:11180000 | lifeskim:mentions | umls-concept:C0206684 | lld:lifeskim |
| pubmed-article:11180000 | lifeskim:mentions | umls-concept:C0524930 | lld:lifeskim |
| pubmed-article:11180000 | lifeskim:mentions | umls-concept:C0920269 | lld:lifeskim |
| pubmed-article:11180000 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:11180000 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11180000 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11180000 | pubmed:abstractText | Sebaceous carcinomas are rare cutaneous appendageal tumors that may occur sporadically or in association with an internal malignancy in Muir-Torre syndrome. In Muir-Torre syndrome microsatellite instability can often be demonstrated in tumor DNA as a result of an inherited mutation in one of several known mismatch repair genes; however, the role of microsatellite instability in sporadic sebaceous carcinomas has not been previously studied. In this report we describe the clinicopathologic characteristics of a series of unselected sebaceous carcinomas and examine them for the presence of microsatellite instability. Of 10 consecutive tumors identified over a 10 y period, only one was from a patient known to have Muir-Torre syndrome. Of the nine presumed sporadic cases, five were from four renal transplant recipients and four from otherwise healthy individuals. Microsatellite instability was demonstrable in three cases: in the Muir-Torre syndrome-associated tumor and in two tumors from transplant patients. Microsatellite instability was subsequently also found in a sebaceous carcinoma from a further transplant patient prospectively sought from another institution. The presence of microsatellite instability in post-transplant sebaceous carcinomas was associated with loss of expression of the mismatch repair protein hMSH2. In summary, sebaceous gland carcinomas, while characteristic of Muir-Torre syndrome, are commonly found outside this context. Among presumed sporadic cases, our data suggest they may be over-represented in immunosuppressed renal transplant recipients. The presence of microsatellite instability in transplant-associated lesions, together with loss of hMSH2 expression suggests that immunosuppression might unmask a previously silent Muir-Torre syndrome phenotype in some cases. Alternatively, there is experimental evidence to suggest that immunosuppressive drugs, most plausibly azathioprine, could select for the emergence of a mutator phenotype and thus predispose to the development of sebaceous carcinomas. The role of mismatch repair defects in other post-transplant skin malignancies remains to be established. | lld:pubmed |
| pubmed-article:11180000 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11180000 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11180000 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11180000 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11180000 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11180000 | pubmed:issn | 0022-202X | lld:pubmed |
| pubmed-article:11180000 | pubmed:author | pubmed-author:HarwoodC ACA | lld:pubmed |
| pubmed-article:11180000 | pubmed:author | pubmed-author:CerioRR | lld:pubmed |
| pubmed-article:11180000 | pubmed:author | pubmed-author:McGregorJ MJM | lld:pubmed |
| pubmed-article:11180000 | pubmed:author | pubmed-author:QuinnA GAG | lld:pubmed |
| pubmed-article:11180000 | pubmed:author | pubmed-author:GhaliLL | lld:pubmed |
| pubmed-article:11180000 | pubmed:author | pubmed-author:K?nevKK | lld:pubmed |
| pubmed-article:11180000 | pubmed:author | pubmed-author:PatelS VSV | lld:pubmed |
| pubmed-article:11180000 | pubmed:author | pubmed-author:Dove-EdwinII | lld:pubmed |
| pubmed-article:11180000 | pubmed:author | pubmed-author:BatailleV AVA | lld:pubmed |
| pubmed-article:11180000 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11180000 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:11180000 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11180000 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11180000 | pubmed:pagination | 246-53 | lld:pubmed |
| pubmed-article:11180000 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11180000 | pubmed:meshHeading | pubmed-meshheading:11180000... | lld:pubmed |
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| pubmed-article:11180000 | pubmed:meshHeading | pubmed-meshheading:11180000... | lld:pubmed |
| pubmed-article:11180000 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11180000 | pubmed:articleTitle | An association between sebaceous carcinoma and microsatellite instability in immunosuppressed organ transplant recipients. | lld:pubmed |
| pubmed-article:11180000 | pubmed:affiliation | Center for Cutaneous Research, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 2 Newark Street, London E1 2AT, UK. caharwood@doctors.org.uk | lld:pubmed |
| pubmed-article:11180000 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11180000 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11180000 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11180000 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11180000 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11180000 | lld:pubmed |
