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pubmed-article:11177250pubmed:abstractTextThe content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopamine, dioxyphenilalanine, and DOPAC by more than 90%. A positive correlation was found between the concentrations of these metabolites in the urine and striatum. Measurement of urinary catecholamines and their metabolites is a perspective test for evaluating the status of the dopaminergic nigrosostriate system of the brain in experimental parkinsonism.lld:pubmed
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pubmed-article:11177250pubmed:articleTitleCatecholamines and their metabolites in the brain and urine of rats with experimental Parkinson's disease.lld:pubmed
pubmed-article:11177250pubmed:affiliationV. P. Serbskii State Center of Social and Forensic Psychiatry, Moscow.lld:pubmed
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