| pubmed-article:11175903 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11175903 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:11175903 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11175903 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:11175903 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:11175903 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:11175903 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:11175903 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11175903 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11175903 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:abstractText | Hu proteins bind to adenosine-uridine (AU)-rich elements (AREs) in the 3' untranslated regions of many short-lived mRNAs, thereby stabilizing them. Here we report the crystal structures of the first two RNA recognition motif (RRM) domains of the HuD protein in complex with an 11-nucleotide fragment of a class I ARE (the c-fos ARE; to 1.8 A), and with an 11-nucleotide fragment of a class II ARE (the tumor necrosis factor alpha ARE; to 2.3 A). These structures reveal a consensus RNA recognition sequence that suggests a preference for pyrimidine-rich sequences and a requirement for a central uracil residue in the clustered AUUUA repeats found in class II AREs. Comparison to structures of other RRM domain-nucleic acid complexes reveals two base recognition pockets in all the structures that interact with bases using residues in conserved ribonucleoprotein motifs and at the C-terminal ends of RRM domains. Different conformations of nucleic acid can be bound by RRM domains by using different combinations of base recognition pockets and multiple RRM domains. | lld:pubmed |
| pubmed-article:11175903 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11175903 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11175903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175903 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11175903 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11175903 | pubmed:issn | 1072-8368 | lld:pubmed |
| pubmed-article:11175903 | pubmed:author | pubmed-author:WangXX | lld:pubmed |
| pubmed-article:11175903 | pubmed:author | pubmed-author:Tanaka... | lld:pubmed |
| pubmed-article:11175903 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11175903 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:11175903 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11175903 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11175903 | pubmed:pagination | 141-5 | lld:pubmed |
| pubmed-article:11175903 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:meshHeading | pubmed-meshheading:11175903... | lld:pubmed |
| pubmed-article:11175903 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11175903 | pubmed:articleTitle | Structural basis for recognition of AU-rich element RNA by the HuD protein. | lld:pubmed |
| pubmed-article:11175903 | pubmed:affiliation | Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. | lld:pubmed |
| pubmed-article:11175903 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:1996 | entrezgene:pubmed | pubmed-article:11175903 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175903 | lld:pubmed |
