| pubmed-article:11175263 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C0257694 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C2347338 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11175263 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11175263 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:11175263 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11175263 | pubmed:abstractText | Deletion of autoreactive thymocytes at the DP stage is the basis for tolerance to thymus-expressed self antigens. In this study we investigated whether distinct signalling pathways are induced in DP thymocytes as compared to mature T cells upon stimulation with antigen. Using triple transgenic mice expressing a TCR transgene, dominant negative ras/Mek proteins and a reporter gene construct with AP-1 or NF-kappa B binding sites, we showed a complete lack of transcriptional activity of NF-kappa B but not AP-1 in DP thymocytes, whereas both were transcriptionally active in mature T cells after antigenic stimulation. Lack of NF-kappa B induction correlated with increased death in response to antigen. AP-1 induction was dependent on the integrity of the ras/Mek pathway indicating that this pathway was activated in the DP thymocytes. In contrast, we found a complete lack of constitutive expression of the epsilon isoform of Protein Kinase C (PKC) in DP thymocytes, although it was present in mature thymocytes and peripheral T cells. Taken together the results suggest that the lack of PKC epsilon in DP thymocytes could lead to the absence of NF-kappa B activity after antigenic stimulation contributing to negative selection. Cell Death and Differentiation (2000) 7, 1253 - 1262. | lld:pubmed |
| pubmed-article:11175263 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11175263 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11175263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11175263 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11175263 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11175263 | pubmed:issn | 1350-9047 | lld:pubmed |
| pubmed-article:11175263 | pubmed:author | pubmed-author:GhoshSS | lld:pubmed |
| pubmed-article:11175263 | pubmed:author | pubmed-author:FlavellR ARA | lld:pubmed |
| pubmed-article:11175263 | pubmed:author | pubmed-author:Schmitt-Verhu... | lld:pubmed |
| pubmed-article:11175263 | pubmed:author | pubmed-author:BoyerCC | lld:pubmed |
| pubmed-article:11175263 | pubmed:author | pubmed-author:RincónMM | lld:pubmed |
| pubmed-article:11175263 | pubmed:author | pubmed-author:AuphanNN | lld:pubmed |
| pubmed-article:11175263 | pubmed:author | pubmed-author:SimonA KAK | lld:pubmed |
| pubmed-article:11175263 | pubmed:author | pubmed-author:PophillatMM | lld:pubmed |
| pubmed-article:11175263 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11175263 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:11175263 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11175263 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11175263 | pubmed:pagination | 1253-62 | lld:pubmed |
| pubmed-article:11175263 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
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| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:meshHeading | pubmed-meshheading:11175263... | lld:pubmed |
| pubmed-article:11175263 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11175263 | pubmed:articleTitle | The lack of NF-kappa B transactivation and PKC epsilon expression in CD4(+)CD8(+) thymocytes correlates with negative selection. | lld:pubmed |
| pubmed-article:11175263 | pubmed:affiliation | Centre d'Immunologie INSERM-CNRS de Marseille Luminy, Marseille, France. katja.simon@ndm.ox.ac.uk | lld:pubmed |
| pubmed-article:11175263 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11175263 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11175263 | lld:pubmed |
