| pubmed-article:11172736 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11172736 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11172736 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:11172736 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:11172736 | lifeskim:mentions | umls-concept:C0029418 | lld:lifeskim |
| pubmed-article:11172736 | lifeskim:mentions | umls-concept:C0029463 | lld:lifeskim |
| pubmed-article:11172736 | lifeskim:mentions | umls-concept:C0014563 | lld:lifeskim |
| pubmed-article:11172736 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:11172736 | lifeskim:mentions | umls-concept:C1155125 | lld:lifeskim |
| pubmed-article:11172736 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:11172736 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11172736 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11172736 | pubmed:abstractText | Epinephrine increased gene- and protein-expression of interleukin-6 (IL-6) and interleukin-11 (IL-11), which are capable of stimulating the development of osteoclasts from their hematopoietic precursors, in human osteoblast (SaM-1) and human osteosarcoma (SaOS-2, HOS, and MG-63) cell lines. An increase in IL-6 and IL-11 synthesis in response to epinephrine appeared to be a common feature in osteoblastic cells, but the magnitude of expression was different in these cell lines. In HOS cells treated with epinephrine, increases of IL-6 and IL-11 synthesis were inhibited by timolol (a beta-blocker), H-89 (N-[2-((p-bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide; an inhibitor of protein kinase A (PKA)) and SB203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole; an inhibitor of p38 mitogen-activated protein kinase (MAPK)], but not by phentolamine (an alpha-blocker), calphostin C [an inhibitor of protein kinase C (PKC)], or PD98059 (2'-amino-3'-methoxyflavone; an inhibitor of classic MAPK), suggesting a common pathway mediated by beta-adrenergic receptors in the PKA and p38 systems involved in the signal transduction of IL-6 and IL-11. Furthermore, expression of both genes was inhibited by curcumin [an inhibitor of activating protein-1 (AP-1) activation], but not by pyrrolidine dithiocarbamate (PDTC) [an inhibitor of nuclear factor (NF)-kappaB]. The pharmacological study suggested that coinduction of the two genes in response to epinephrine occurred via activation of AP-1. The findings of the present study suggest that coinduction of IL-6 and IL-11 in response to epinephrine probably occurs via the PKA and p38 MAPK systems, leading to the transcriptional activation of AP-1 in human osteoblastic cells. | lld:pubmed |
| pubmed-article:11172736 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11172736 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11172736 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11172736 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11172736 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:11172736 | pubmed:author | pubmed-author:KondoAA | lld:pubmed |
| pubmed-article:11172736 | pubmed:author | pubmed-author:MogiMM | lld:pubmed |
| pubmed-article:11172736 | pubmed:author | pubmed-author:KoshiharaYY | lld:pubmed |
| pubmed-article:11172736 | pubmed:author | pubmed-author:TogariAA | lld:pubmed |
| pubmed-article:11172736 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11172736 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11172736 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:11172736 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11172736 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11172736 | pubmed:pagination | 319-26 | lld:pubmed |
| pubmed-article:11172736 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11172736 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11172736 | pubmed:articleTitle | Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells. | lld:pubmed |
| pubmed-article:11172736 | pubmed:affiliation | Department of Pharmacology, School of Dentistry, Aichi-Gakuin University, 464-8650, Nagoya, Japan. | lld:pubmed |
| pubmed-article:11172736 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11172736 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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