| pubmed-article:11171967 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11171967 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:11171967 | lifeskim:mentions | umls-concept:C0007623 | lld:lifeskim |
| pubmed-article:11171967 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:11171967 | lifeskim:mentions | umls-concept:C1261552 | lld:lifeskim |
| pubmed-article:11171967 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:11171967 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11171967 | pubmed:dateCreated | 2001-2-26 | lld:pubmed |
| pubmed-article:11171967 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11171967 | pubmed:abstractText | The cell wall imparts structural strength and shape to bacteria. It is made up of polymeric glycan chains with peptide branches that are cross-linked to form the cell wall. The cross-linking reaction, catalyzed by transpeptidases, is the last step in cell wall biosynthesis. These enzymes are members of the family of penicillin-binding proteins, the targets of beta-lactam antibiotics. We report herein the structure of a penicillin-binding protein complexed with a cephalosporin designed to probe the mechanism of the cross-linking reaction catalyzed by transpeptidases. The 1.2-A resolution x-ray structure of this cephalosporin bound to the active site of the bifunctional serine type D-alanyl-D-alanine carboxypeptidase/transpeptidase (EC ) from Streptomyces sp. strain R61 reveals how the two peptide strands from the polymeric substrates are sequestered in the active site of a transpeptidase. The structure of this complex provides a snapshot of the enzyme and the bound cell wall components poised for the final and critical cross-linking step of cell wall biosynthesis. | lld:pubmed |
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| pubmed-article:11171967 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11171967 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11171967 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11171967 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11171967 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11171967 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11171967 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11171967 | pubmed:author | pubmed-author:TakedaYY | lld:pubmed |
| pubmed-article:11171967 | pubmed:author | pubmed-author:LeaSS | lld:pubmed |
| pubmed-article:11171967 | pubmed:author | pubmed-author:KellyJ AJA | lld:pubmed |
| pubmed-article:11171967 | pubmed:author | pubmed-author:LiZ HZH | lld:pubmed |
| pubmed-article:11171967 | pubmed:author | pubmed-author:MobasherySS | lld:pubmed |
| pubmed-article:11171967 | pubmed:author | pubmed-author:McDonoughM... | lld:pubmed |
| pubmed-article:11171967 | pubmed:author | pubmed-author:KotraLL | lld:pubmed |
| pubmed-article:11171967 | pubmed:author | pubmed-author:SilvaggiN RNR | lld:pubmed |
| pubmed-article:11171967 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11171967 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:11171967 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11171967 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11171967 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11171967 | pubmed:pagination | 1427-31 | lld:pubmed |
| pubmed-article:11171967 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11171967 | pubmed:meshHeading | pubmed-meshheading:11171967... | lld:pubmed |
| pubmed-article:11171967 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11171967 | pubmed:articleTitle | A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. | lld:pubmed |
| pubmed-article:11171967 | pubmed:affiliation | Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269-3125, USA. | lld:pubmed |
| pubmed-article:11171967 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11171967 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11171967 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:11171967 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| family:PF02557.12 | family:pubmed | pubmed-article:11171967 | lld:pfam |
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