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pubmed-article:11170832pubmed:abstractTextThe placenta must allow the passage of iodide from the maternal to the fetal circulation for synthesis of thyroxine by the fetal thyroid. The thyroid sodium iodide symporter (NIS) was cloned in 1996 and, although widely distributed among epithelial tissues, early studies failed to detect it in placenta. We demonstrated NIS mRNA in human placenta and in the human choriocarcinoma cell line, JAr. NIS protein was localized to trophoblasts, with a tendency to apical distribution, in sections of human placenta immunostained with a monoclonal antibody against hNIS. We conclude that NIS is expressed in placenta and may mediate placental iodide transport.lld:pubmed
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pubmed-article:11170832pubmed:authorpubmed-author:MortimerR HRHlld:pubmed
pubmed-article:11170832pubmed:authorpubmed-author:ManleyS WSWlld:pubmed
pubmed-article:11170832pubmed:authorpubmed-author:PowellK AKAlld:pubmed
pubmed-article:11170832pubmed:authorpubmed-author:MitchellA MAMlld:pubmed
pubmed-article:11170832pubmed:authorpubmed-author:MorrisJ CJClld:pubmed
pubmed-article:11170832pubmed:authorpubmed-author:BergertE RERlld:pubmed
pubmed-article:11170832pubmed:copyrightInfoCopyright 2001 Harcourt Publishers Ltd.lld:pubmed
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pubmed-article:11170832pubmed:dateRevised2005-11-17lld:pubmed
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pubmed-article:11170832pubmed:articleTitleSodium iodide symporter (NIS) gene expression in human placenta.lld:pubmed
pubmed-article:11170832pubmed:affiliationRoyal Brisbane Hospital Research Foundation, Bancroft Centre, Clinical Research Centre, Brisbane, QLD 4029, Australia. agnieszM@qimr.edu.aulld:pubmed
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