| pubmed-article:11169953 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11169953 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:11169953 | lifeskim:mentions | umls-concept:C0062503 | lld:lifeskim |
| pubmed-article:11169953 | lifeskim:mentions | umls-concept:C0007102 | lld:lifeskim |
| pubmed-article:11169953 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:11169953 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:11169953 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:11169953 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11169953 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11169953 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11169953 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11169953 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11169953 | pubmed:abstractText | We investigated the effect of hepatocyte-derived extracellular matrix (ECM) on the expression of erb-B2 and erb-B3 in colon cancer cell lines, as well as the role of erb-B2 and erb-B3 in colon cancer cell proliferation. Colon cancer cell lines plated on hepatocyte-derived ECM had increased protein levels of both erb-B2 and erb-B3. The addition of soluble recombinant proteoglycan syndecan-4 also resulted in higher expression of erb-B2 and erb-B3. We prepared hepatocyte-derived ECM from 1 to 7 days' cultures of hepatocytes, which contained different amounts of sulfated glycosaminoglycans. There was a direct correlation between the amounts of sulfated glycosaminoglycans in the ECM and the levels of erb-B2 and erb-B3 in the colon cell line KM12. The stimulatory effect of hepatocyte-derived ECM was abolished when the colon cancer cells were cultured in the presence of antibodies to erb-B2. These studies show that hepatocyte-derived ECM and the heparan sulfate proteoglycans present in it are responsible for inducing erb-B2 and erb-B3 in colon cancer cells. The growth stimulatory effect of extracellular matrix is mediated, at least in part, by increased expression of erb-B2 and erb-B3. | lld:pubmed |
| pubmed-article:11169953 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11169953 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11169953 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11169953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11169953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11169953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11169953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11169953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11169953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11169953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11169953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11169953 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11169953 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11169953 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:11169953 | pubmed:author | pubmed-author:BrillSS | lld:pubmed |
| pubmed-article:11169953 | pubmed:author | pubmed-author:MoskovitzSS | lld:pubmed |
| pubmed-article:11169953 | pubmed:author | pubmed-author:PapiEE | lld:pubmed |
| pubmed-article:11169953 | pubmed:author | pubmed-author:YayonAA | lld:pubmed |
| pubmed-article:11169953 | pubmed:author | pubmed-author:HalpernZZ | lld:pubmed |
| pubmed-article:11169953 | pubmed:author | pubmed-author:ZvibelII | lld:pubmed |
| pubmed-article:11169953 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11169953 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11169953 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:11169953 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11169953 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11169953 | pubmed:pagination | 316-21 | lld:pubmed |
| pubmed-article:11169953 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:11169953 | pubmed:meshHeading | pubmed-meshheading:11169953... | lld:pubmed |
| pubmed-article:11169953 | pubmed:meshHeading | pubmed-meshheading:11169953... | lld:pubmed |
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| pubmed-article:11169953 | pubmed:meshHeading | pubmed-meshheading:11169953... | lld:pubmed |
| pubmed-article:11169953 | pubmed:meshHeading | pubmed-meshheading:11169953... | lld:pubmed |
| pubmed-article:11169953 | pubmed:meshHeading | pubmed-meshheading:11169953... | lld:pubmed |
| pubmed-article:11169953 | pubmed:meshHeading | pubmed-meshheading:11169953... | lld:pubmed |
| pubmed-article:11169953 | pubmed:meshHeading | pubmed-meshheading:11169953... | lld:pubmed |
| pubmed-article:11169953 | pubmed:meshHeading | pubmed-meshheading:11169953... | lld:pubmed |
| pubmed-article:11169953 | pubmed:meshHeading | pubmed-meshheading:11169953... | lld:pubmed |
| pubmed-article:11169953 | pubmed:meshHeading | pubmed-meshheading:11169953... | lld:pubmed |
| pubmed-article:11169953 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11169953 | pubmed:articleTitle | Soluble and matrix-associated heparan sulfate proteoglycans increase expression of erb-B2 and erb-B3 in colon cancer cell lines. | lld:pubmed |
| pubmed-article:11169953 | pubmed:affiliation | Liver Metastasis Research Group, Gastroenterology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. isab@tasmc.health.gov.il | lld:pubmed |
| pubmed-article:11169953 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11169953 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
