| pubmed-article:11167801 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C0427526 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:11167801 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:11167801 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11167801 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11167801 | pubmed:abstractText | Large granular lymphocyte (LGL) leukaemia is a disease with increased numbers of circulating granular lymphocytes and an increased percentage of clonally rearranged CD8(+)CD57(+) cells. To determine whether LGL cells are also found in other lymphocyte subsets, CD8(+) cells from 10 LGL patients were sorted into CD57(+) and CD57(-) fractions and analysed for clonality using a T-cell receptor gamma (TCR gamma) polymerase chain reaction (PCR). In nine patients, a clonal TCR rearrangement was identified in the CD8(+)CD57(+) cells, and in one patient, the TCR rearrangement was oligoclonal in the CD8(+)CD57(+) fraction. In eight out of nine of the clonally rearranged patients, the same band was also present in the CD8(+)CD57(-) fraction. To define the relationship between CD57(-) and CD57(+) LGL populations, CD8(+)CD57(-) and CD8(+)CD57(+) cells were sorted from five patients and cultured in the presence of anti-CD3 plus CD28 antibodies. The CD57(+) cells died of apoptosis before d 7, while the CD57(-) cells proliferated and differentiated into CD57(+) cells. Clonal analysis identified the same band in both cultured subpopulations and in the uncultured CD8(+) cells. Immunophenotypical analysis showed that CD8(+)CD57(-) cells expressed memory cell markers, while the CD8(+)CD57(+) cells exhibited effector characteristics. These results suggest that LGL disease originates in a CD57(-) memory T-cell compartment that continually generates CD57(+) (effector cell) progeny. | lld:pubmed |
| pubmed-article:11167801 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11167801 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11167801 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11167801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11167801 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11167801 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11167801 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:11167801 | pubmed:author | pubmed-author:BarrettA JAJ | lld:pubmed |
| pubmed-article:11167801 | pubmed:author | pubmed-author:KirbyMM | lld:pubmed |
| pubmed-article:11167801 | pubmed:author | pubmed-author:SorbaraLL | lld:pubmed |
| pubmed-article:11167801 | pubmed:author | pubmed-author:MelenhorstJ... | lld:pubmed |
| pubmed-article:11167801 | pubmed:author | pubmed-author:HenselN FNF | lld:pubmed |
| pubmed-article:11167801 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11167801 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:11167801 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11167801 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11167801 | pubmed:pagination | 189-94 | lld:pubmed |
| pubmed-article:11167801 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:11167801 | pubmed:meshHeading | pubmed-meshheading:11167801... | lld:pubmed |
| pubmed-article:11167801 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11167801 | pubmed:articleTitle | Large granular lymphocyte leukaemia is characterized by a clonal T-cell receptor rearrangement in both memory and effector CD8(+) lymphocyte populations. | lld:pubmed |
| pubmed-article:11167801 | pubmed:affiliation | Bone Marrow transplant Unit, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. melenhoj@nih.gov | lld:pubmed |
| pubmed-article:11167801 | pubmed:publicationType | Journal Article | lld:pubmed |
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