| pubmed-article:11166513 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11166513 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11166513 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:11166513 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:11166513 | lifeskim:mentions | umls-concept:C0031937 | lld:lifeskim |
| pubmed-article:11166513 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:11166513 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:11166513 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:11166513 | lifeskim:mentions | umls-concept:C2827063 | lld:lifeskim |
| pubmed-article:11166513 | lifeskim:mentions | umls-concept:C0290799 | lld:lifeskim |
| pubmed-article:11166513 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11166513 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11166513 | pubmed:abstractText | Augmentation of selective serotonin reuptake inhibitors (SSRIs) therapy by the 5-HT(1A) receptor agent pindolol may reduce the delay between initiation of antidepressant treatment and clinical response. This hypothesis is based on the ability of pindolol to block 5-HT(1A) autoreceptors in the dorsal raphe nuclei (DRN) and to potentiate the increase in 5-HT transmission induced by SSRIs. However, placebo-controlled clinical studies of pindolol augmentation of antidepressant therapy have reported inconsistent results. Here, we evaluated the occupancy of 5-HT(1A) receptors during treatment with pindolol controlled release (CR) in nine healthy volunteers with Positron Emission Tomography and [11C]WAY 100635. Subjects were studied four times: at baseline, following one week of pindolol CR 7.5 mg/day (4 and 10 hrs post dose), and following one dose of pindolol CR 30 mg(4 hrs post dose). Occupancy of the DRN was 40 +/- 29% on scan 2, 38 +/- 26% on scan 3, and 64 +/- 15% on scan 4. The average occupancy in all other regions was significantly lower at each doses (18 +/- 5% on scan 2, 12 +/- 3% on scan 3, and 42 +/- 4% on scan 4). These results suggest that the blockade in the DRN reached in clinical studies (7.5 mg/day) might be too low and variable to consistently augment the therapeutic effect of SSRIs. However, these data indicate that pindolol exhibits in vivo selectivity for the DRN 5-HT(1A) autoreceptors. As DRN selectivity is desirable for potentiation of 5-HT function, this observation represents an important proof of concept for the development of 5-HT(1A) agents in this application. | lld:pubmed |
| pubmed-article:11166513 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11166513 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11166513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166513 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11166513 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11166513 | pubmed:issn | 0893-133X | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:HashimotoTT | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:KentJJ | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:MartinezDD | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:HuangYY | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:SimpsonNN | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:MannJ JJJ | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:LaruelleMM | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:Abi-DarghamAA | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:HwangDD | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:ShinaRR | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:ParseyR VRV | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:CaltabianoSS | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:MaliziaAA | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:Van HeertumRR | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:CowleyHH | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:MawlawiOO | lld:pubmed |
| pubmed-article:11166513 | pubmed:author | pubmed-author:SlifsteinMM | lld:pubmed |
| pubmed-article:11166513 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11166513 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:11166513 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11166513 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11166513 | pubmed:pagination | 209-29 | lld:pubmed |
| pubmed-article:11166513 | pubmed:dateRevised | 2011-5-18 | lld:pubmed |
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| pubmed-article:11166513 | pubmed:meshHeading | pubmed-meshheading:11166513... | lld:pubmed |
| pubmed-article:11166513 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11166513 | pubmed:articleTitle | Differential occupancy of somatodendritic and postsynaptic 5HT(1A) receptors by pindolol: a dose-occupancy study with [11C]WAY 100635 and positron emission tomography in humans. | lld:pubmed |
| pubmed-article:11166513 | pubmed:affiliation | Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA. | lld:pubmed |
| pubmed-article:11166513 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11166513 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11166513 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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