Linked Life Data

11163758

Source:http://linkedlifedata.com/resource/pubmed/id/11163758

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:11163758rdf:typepubmed:Citationlld:pubmed
pubmed-article:11163758lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:11163758lifeskim:mentionsumls-concept:C0162638lld:lifeskim
pubmed-article:11163758lifeskim:mentionsumls-concept:C0431085lld:lifeskim
pubmed-article:11163758lifeskim:mentionsumls-concept:C0087071lld:lifeskim
pubmed-article:11163758lifeskim:mentionsumls-concept:C0063146lld:lifeskim
pubmed-article:11163758lifeskim:mentionsumls-concept:C0021467lld:lifeskim
pubmed-article:11163758lifeskim:mentionsumls-concept:C0332281lld:lifeskim
pubmed-article:11163758lifeskim:mentionsumls-concept:C1515263lld:lifeskim
pubmed-article:11163758lifeskim:mentionsumls-concept:C1159825lld:lifeskim
pubmed-article:11163758lifeskim:mentionsumls-concept:C0021469lld:lifeskim
pubmed-article:11163758pubmed:issue3lld:pubmed
pubmed-article:11163758pubmed:dateCreated2001-2-22lld:pubmed
pubmed-article:11163758pubmed:abstractTextReactive oxygen species (ROS) have been found to trigger apoptosis in tumor cells. At the same time, telomerase is found to be associated with malignancy and reduced apoptosis. However little is known about the linkage between ROS such as *OH and telomerase/telomere. To address the interrelations between *OH and telomerase/telomere in tumor cell killing, HeLa, 293 and MW451 cells were induced to undergo apoptosis with *OH radicals generated via Fe(2+)-mediated Fenton reactions (0.1 mM FeSO(4) plus 0.3-0.9 mM H2O2) and telomerase activity, telomere length were measured during apoptosis. We found that during *OH-induced apoptosis, telomere shortening took place while no changes in telomerase activity were observed. Our results suggest that *OH-induced telomere shortening is not through telomerase inhibition but possibly a direct effect of *OH on telomeres themselves indicating that telomere shortening but not telomerase inhibition is the primary event during *OH-induced apoptosis. Strikingly, we also found that *OH-induced apoptosis in HeLa cells is caspase-3-independent but is associated with reduction of mitochondrial transmembrane potential. Our results indicate that *OH triggers apoptotic tumor cell death through a telomere-related, caspase-independent pathway.lld:pubmed
pubmed-article:11163758pubmed:languageenglld:pubmed
pubmed-article:11163758pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11163758pubmed:citationSubsetIMlld:pubmed
pubmed-article:11163758pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11163758pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11163758pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11163758pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11163758pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11163758pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11163758pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11163758pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11163758pubmed:statusMEDLINElld:pubmed
pubmed-article:11163758pubmed:monthJanlld:pubmed
pubmed-article:11163758pubmed:issn0014-5793lld:pubmed
pubmed-article:11163758pubmed:authorpubmed-author:SenK KKKlld:pubmed
pubmed-article:11163758pubmed:authorpubmed-author:JustTTlld:pubmed
pubmed-article:11163758pubmed:authorpubmed-author:DaiY RYRlld:pubmed
pubmed-article:11163758pubmed:authorpubmed-author:XiaH LHLlld:pubmed
pubmed-article:11163758pubmed:issnTypePrintlld:pubmed
pubmed-article:11163758pubmed:day19lld:pubmed
pubmed-article:11163758pubmed:volume488lld:pubmed
pubmed-article:11163758pubmed:ownerNLMlld:pubmed
pubmed-article:11163758pubmed:authorsCompleteYlld:pubmed
pubmed-article:11163758pubmed:pagination123-32lld:pubmed
pubmed-article:11163758pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:meshHeadingpubmed-meshheading:11163758...lld:pubmed
pubmed-article:11163758pubmed:year2001lld:pubmed
pubmed-article:11163758pubmed:articleTitleHydroxyl radical-induced apoptosis in human tumor cells is associated with telomere shortening but not telomerase inhibition and caspase activation.lld:pubmed
pubmed-article:11163758pubmed:affiliationDepartment of Biological Sciences and Biotechnology, Tsinghua University, Beijing, PR China.lld:pubmed
pubmed-article:11163758pubmed:publicationTypeJournal Articlelld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11163758lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11163758lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11163758lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11163758lld:pubmed