| pubmed-article:11163237 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11163237 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11163237 | lifeskim:mentions | umls-concept:C0023473 | lld:lifeskim |
| pubmed-article:11163237 | lifeskim:mentions | umls-concept:C2350052 | lld:lifeskim |
| pubmed-article:11163237 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:11163237 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11163237 | lifeskim:mentions | umls-concept:C0439677 | lld:lifeskim |
| pubmed-article:11163237 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:11163237 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11163237 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11163237 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11163237 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11163237 | pubmed:abstractText | The functions of JunB during myelopoiesis were studied in vivo. Transgenic mice specifically lacking JunB expression in the myeloid lineage (junB(-/-)Ubi-junB mice) develop a transplantable myeloproliferative disease eventually progressing to blast crisis, which resembles human chronic myeloid leukemia. Similarly, mice reconstituted with ES cell-derived junB-/- fetal liver cells also develop a myeloproliferative disease. In both cases, the absence of JunB expression results in increased numbers of granulocyte progenitors, which display enhanced GM-CSF-mediated proliferation and extended survival, associated with changes in the expression levels of the GM-CSFalpha receptor, the anti-apoptotic proteins Bcl2 and Bclx, and the cell cycle regulators p16(INK4a) and c-Jun. Importantly, ectopic expression of JunB fully reverts the immature and hyperproliferative phenotype of JunB-deficient myeloid cells. These results identify JunB as a key transcriptional regulator of myelopoiesis and a potential tumor suppressor gene. | lld:pubmed |
| pubmed-article:11163237 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11163237 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11163237 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11163237 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11163237 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11163237 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11163237 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11163237 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:11163237 | pubmed:author | pubmed-author:WagnerE FEF | lld:pubmed |
| pubmed-article:11163237 | pubmed:author | pubmed-author:PasseguéEE | lld:pubmed |
| pubmed-article:11163237 | pubmed:author | pubmed-author:Möhle-Steinle... | lld:pubmed |
| pubmed-article:11163237 | pubmed:author | pubmed-author:JochumWW | lld:pubmed |
| pubmed-article:11163237 | pubmed:author | pubmed-author:Schorpp-Kistn... | lld:pubmed |
| pubmed-article:11163237 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11163237 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:11163237 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:11163237 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11163237 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11163237 | pubmed:pagination | 21-32 | lld:pubmed |
| pubmed-article:11163237 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11163237 | pubmed:meshHeading | pubmed-meshheading:11163237... | lld:pubmed |
| pubmed-article:11163237 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11163237 | pubmed:articleTitle | Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage. | lld:pubmed |
| pubmed-article:11163237 | pubmed:affiliation | Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. | lld:pubmed |
| pubmed-article:11163237 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11163237 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:11163237 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16477 | entrezgene:pubmed | pubmed-article:11163237 | lld:entrezgene |
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