| pubmed-article:11162815 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11162815 | lifeskim:mentions | umls-concept:C0019707 | lld:lifeskim |
| pubmed-article:11162815 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11162815 | lifeskim:mentions | umls-concept:C0016674 | lld:lifeskim |
| pubmed-article:11162815 | lifeskim:mentions | umls-concept:C2827666 | lld:lifeskim |
| pubmed-article:11162815 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11162815 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
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| pubmed-article:11162815 | pubmed:abstractText | To determine the prevalence of human immunodeficiency virus type 2 (HIV-2) subtypes circulating in France and to identify possible relationships between these subtypes and pathogenesis, we studied 33 HIV-2-infected patients living in France. HIV-2 DNA was directly amplified from peripheral blood mononuclear cells by nested PCR with specific HIV-2 env primers, and the env gene was sequenced. The serological consequences of antigenic variability were studied by using a panel of peptides and by Western blotting. Phylogenetic analysis classified the 33 HIV-2 strains as subtype A (n = 23) or B (n = 10). There were no significant clinical or epidemiological differences between patients infected with either of these two subtypes. There was some evidence for geographical clustering. Subtype A strains from patients originating from the Cape Verde Islands and Guinea Bissau clustered together. The majority of patients infected with subtype B strains originated from the Ivory Coast or Mali. Strains from patients originating in Mali also clustered in subtype A but distinctly from the Cape Verde or Guinea Bissau strains. The subtype B strains showed greater diversity and included some highly divergent strains relative to those previously characterized. The V3 loop of HIV-2 subtypes A and B was found to be quite conserved in comparison with HIV-1. A strong HIV-2 subtype B serological cross-reactivity was found on HIV-1 env antigen by Western blot mostly in the gp41 transmembrane glycoprotein. This could partly explain the double HIV-1 and HIV-2 reactive profiles found in countries where HIV-2 subtype B is prevalent. | lld:pubmed |
| pubmed-article:11162815 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11162815 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11162815 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11162815 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11162815 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:11162815 | pubmed:author | pubmed-author:RobertsonD... | lld:pubmed |
| pubmed-article:11162815 | pubmed:author | pubmed-author:SimonFF | lld:pubmed |
| pubmed-article:11162815 | pubmed:author | pubmed-author:Brun-VézinetF... | lld:pubmed |
| pubmed-article:11162815 | pubmed:author | pubmed-author:LeprêtreAA | lld:pubmed |
| pubmed-article:11162815 | pubmed:author | pubmed-author:MatheronSS | lld:pubmed |
| pubmed-article:11162815 | pubmed:author | pubmed-author:ApetreiCC | lld:pubmed |
| pubmed-article:11162815 | pubmed:author | pubmed-author:DamondFF | lld:pubmed |
| pubmed-article:11162815 | pubmed:author | pubmed-author:SouquièreSS | lld:pubmed |
| pubmed-article:11162815 | pubmed:author | pubmed-author:PlantierJ CJC | lld:pubmed |
| pubmed-article:11162815 | pubmed:copyrightInfo | Copyright 2001 Academic Press. | lld:pubmed |
| pubmed-article:11162815 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11162815 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11162815 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:11162815 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11162815 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11162815 | pubmed:pagination | 19-30 | lld:pubmed |
| pubmed-article:11162815 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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