| pubmed-article:11160152 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11160152 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11160152 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:11160152 | lifeskim:mentions | umls-concept:C0032043 | lld:lifeskim |
| pubmed-article:11160152 | lifeskim:mentions | umls-concept:C0125606 | lld:lifeskim |
| pubmed-article:11160152 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:11160152 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11160152 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11160152 | pubmed:abstractText | The placenta may play a critical role in inhibiting vertical transmission of HIV-1. Here we demonstrate that leukemia inhibitory factor (LIF) is a potent endogenous HIV-1-suppressive factor produced locally in placentae. In vitro, LIF exerted a potent, gp130-LIFRbeta-dependent, HIV coreceptor-independent inhibition of HIV-1 replication with IC50 values between 0.1 pg/ml and 0.7 pg/ml, depending on the HIV-1 isolate. LIF also inhibited HIV-1 in placenta and thymus tissues grown in ex vivo organ culture. The level of LIF mRNA and the incidence of LIF protein-expressing cells were significantly greater in placentae from HIV-1-infected women who did not transmit HIV-1 to their fetuses compared with women who transmitted the infection, but they were not significantly different from placentae of uninfected mothers. These findings demonstrate a novel pathway for endogenous HIV suppression that may prove to be an effective immune therapy for HIV infection. | lld:pubmed |
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| pubmed-article:11160152 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11160152 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11160152 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11160152 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11160152 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11160152 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:11160152 | pubmed:author | pubmed-author:AnderssonJJ | lld:pubmed |
| pubmed-article:11160152 | pubmed:author | pubmed-author:KhanNN | lld:pubmed |
| pubmed-article:11160152 | pubmed:author | pubmed-author:YogevRR | lld:pubmed |
| pubmed-article:11160152 | pubmed:author | pubmed-author:LandayAA | lld:pubmed |
| pubmed-article:11160152 | pubmed:author | pubmed-author:KabatW JWJ | lld:pubmed |
| pubmed-article:11160152 | pubmed:author | pubmed-author:SullivanYY | lld:pubmed |
| pubmed-article:11160152 | pubmed:author | pubmed-author:PattersonB... | lld:pubmed |
| pubmed-article:11160152 | pubmed:author | pubmed-author:O'GormanM RMR | lld:pubmed |
| pubmed-article:11160152 | pubmed:author | pubmed-author:BehbahaniHH | lld:pubmed |
| pubmed-article:11160152 | pubmed:author | pubmed-author:FlenerZZ | lld:pubmed |
| pubmed-article:11160152 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11160152 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:11160152 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11160152 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11160152 | pubmed:pagination | 287-94 | lld:pubmed |
| pubmed-article:11160152 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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