| pubmed-article:11158761 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11158761 | lifeskim:mentions | umls-concept:C0003308 | lld:lifeskim |
| pubmed-article:11158761 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:11158761 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:11158761 | lifeskim:mentions | umls-concept:C1268551 | lld:lifeskim |
| pubmed-article:11158761 | lifeskim:mentions | umls-concept:C0537894 | lld:lifeskim |
| pubmed-article:11158761 | lifeskim:mentions | umls-concept:C0537895 | lld:lifeskim |
| pubmed-article:11158761 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11158761 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11158761 | pubmed:abstractText | The pharmacokinetics of the antifungal echinocandin-lipopeptide caspofungin (MK-0991) in plasma were studied in groups of three healthy rabbits after single and multiple daily intravenous administration of doses of 1, 3, and 6 mg/kg of body weight. Concentrations were measured by a validated high-performance liquid chromatography method and fitted into a three-compartment open pharmacokinetic model. Across the investigated dosage range, caspofungin displayed dose-independent pharmacokinetics. Following administration over 7 days, the mean peak concentration in plasma (C(max)) +/- standard error of the mean increased from 16.01 +/- 0.61 microg/ml at the 1-mg/kg dose to 105.52 +/- 8.92 microg/ml at the 6-mg/kg dose; the mean area under the curve from 0 h to infinity rose from 13.15 +/- 2.37 to 158.43 +/- 15.58 microg. h/ml, respectively. The mean apparent volume of distribution at steady state (Vd(ss)) was 0.299 +/- 0.011 liter/kg at the 1-mg/kg dose and 0.351 +/- 0.016 liter/kg at the 6-mg/kg dose (not significant [NS]). Clearance (CL) ranged from 0.086 +/- 0.017 liter/kg/h at the 1-mg/kg dose to 0.043 +/- 0.004 liter/kg/h at the 6-mg/kg dose (NS), and the mean terminal half-life was between 30 and 34 h (NS). Except for a trend towards an increased Vd(ss), there were no significant differences in pharmacokinetic parameters in comparison to those after single-dose administration. Caspofungin was well tolerated, displayed linear pharmacokinetics that fit into a three-compartment pharmacokinetic model, and achieved sustained concentrations in plasma that were multiple times in excess of reported MICs for susceptible opportunistic fungi. | lld:pubmed |
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| pubmed-article:11158761 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11158761 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158761 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11158761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11158761 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11158761 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11158761 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:11158761 | pubmed:author | pubmed-author:WalshT JTJ | lld:pubmed |
| pubmed-article:11158761 | pubmed:author | pubmed-author:PiscitelliS... | lld:pubmed |
| pubmed-article:11158761 | pubmed:author | pubmed-author:GrollA HAH | lld:pubmed |
| pubmed-article:11158761 | pubmed:author | pubmed-author:PetraitisVV | lld:pubmed |
| pubmed-article:11158761 | pubmed:author | pubmed-author:PetraitieneRR | lld:pubmed |
| pubmed-article:11158761 | pubmed:author | pubmed-author:CandelarioMM | lld:pubmed |
| pubmed-article:11158761 | pubmed:author | pubmed-author:GullickB MBM | lld:pubmed |
| pubmed-article:11158761 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11158761 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:11158761 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11158761 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11158761 | pubmed:pagination | 596-600 | lld:pubmed |
| pubmed-article:11158761 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11158761 | pubmed:meshHeading | pubmed-meshheading:11158761... | lld:pubmed |
| pubmed-article:11158761 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11158761 | pubmed:articleTitle | Compartmental pharmacokinetics of the antifungal echinocandin caspofungin (MK-0991) in rabbits. | lld:pubmed |
| pubmed-article:11158761 | pubmed:affiliation | Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:11158761 | pubmed:publicationType | Journal Article | lld:pubmed |
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