| pubmed-article:11157052 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C0162508 | lld:lifeskim |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C1367731 | lld:lifeskim |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C1334482 | lld:lifeskim |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C1150587 | lld:lifeskim |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C1705632 | lld:lifeskim |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C2610891 | lld:lifeskim |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C2348205 | lld:lifeskim |
| pubmed-article:11157052 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:11157052 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11157052 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11157052 | pubmed:abstractText | Apoptotic and mitogenic stimuli activate c-Jun NH2-terminal kinases (JNKs) in T cells. Although T cells express both JNK1 and JNK2 isozymes, the absence of JNK2 alone can result in resistance to anti-CD3-induced thymocyte apoptosis and defective mature T cell proliferation. Similar defects in thymocyte apoptosis and mature T cell proliferation, the latter due to reduced interleukin 2 production, are also caused by JNK1 deficiency. Importantly, T cell function was compromised in Jnk1(+/-)Jnk2(+/-) double heterozygous mice, indicating that JNK1 and JNK2 play similar roles in regulating T cell function. The reduced JNK dose results in defective c-Jun NH2-terminal phosphorylation in thymocytes but not in peripheral T cells, in which nuclear factors of activated T cells (NK-ATs)-DNA binding activity is affected. Thus, JNK1 and JNK2 control similar functions during T cell maturation through differential targeting of distinct substrates. | lld:pubmed |
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| pubmed-article:11157052 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11157052 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11157052 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11157052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11157052 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11157052 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11157052 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:11157052 | pubmed:author | pubmed-author:WagnerE FEF | lld:pubmed |
| pubmed-article:11157052 | pubmed:author | pubmed-author:GraefII | lld:pubmed |
| pubmed-article:11157052 | pubmed:author | pubmed-author:KarinMM | lld:pubmed |
| pubmed-article:11157052 | pubmed:author | pubmed-author:KallunkiTT | lld:pubmed |
| pubmed-article:11157052 | pubmed:author | pubmed-author:DavidJ PJP | lld:pubmed |
| pubmed-article:11157052 | pubmed:author | pubmed-author:SabapathyKK | lld:pubmed |
| pubmed-article:11157052 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11157052 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:11157052 | pubmed:volume | 193 | lld:pubmed |
| pubmed-article:11157052 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11157052 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11157052 | pubmed:pagination | 317-28 | lld:pubmed |
| pubmed-article:11157052 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11157052 | pubmed:meshHeading | pubmed-meshheading:11157052... | lld:pubmed |
| pubmed-article:11157052 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11157052 | pubmed:articleTitle | c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. | lld:pubmed |
