| pubmed-article:11146898 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11146898 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:11146898 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:11146898 | lifeskim:mentions | umls-concept:C0683149 | lld:lifeskim |
| pubmed-article:11146898 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:11146898 | lifeskim:mentions | umls-concept:C0724001 | lld:lifeskim |
| pubmed-article:11146898 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:11146898 | pubmed:dateCreated | 2001-1-5 | lld:pubmed |
| pubmed-article:11146898 | pubmed:abstractText | The aim of this study was to determine the possible mechanism of the antiviral activity of twice daily administration of interferon (IFN)-alpha for active hepatitis C and to evaluate serum concentrations of IFN-alpha with enzyme-linked immunosorbent assay (ELISA). Forty-seven patients with active hepatitis C received IFN-alpha intramuscularly for 24 weeks. They were divided into once-a-day and twice-a-day groups. Changes in serum IFN-alpha levels were assessed during the treatment period. Compared with twice-a-day treatment, the once-a-day group showed no increase in serum IFN-alpha at the end of daily treatment (p < 0.03). In contrast, one-third of the twice-a-day group showed increased IFN-alpha at the end of daily treatment (p < 0.02). In conclusion, measured with ELISA, twice-daily administration of IFN-alpha manifested prolonged elevation in serum levels when compared with once daily administration. | lld:pubmed |
| pubmed-article:11146898 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11146898 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11146898 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11146898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11146898 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11146898 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11146898 | pubmed:issn | 0251-1649 | lld:pubmed |
| pubmed-article:11146898 | pubmed:author | pubmed-author:TanakaNN | lld:pubmed |
| pubmed-article:11146898 | pubmed:author | pubmed-author:HorieTT | lld:pubmed |
| pubmed-article:11146898 | pubmed:author | pubmed-author:MatsuuraMM | lld:pubmed |
| pubmed-article:11146898 | pubmed:author | pubmed-author:KojimaTT | lld:pubmed |
| pubmed-article:11146898 | pubmed:author | pubmed-author:ArakawaYY | lld:pubmed |
| pubmed-article:11146898 | pubmed:author | pubmed-author:NishinaritaSS | lld:pubmed |
| pubmed-article:11146898 | pubmed:author | pubmed-author:MoriyamaMM | lld:pubmed |
| pubmed-article:11146898 | pubmed:author | pubmed-author:KameiSS | lld:pubmed |
| pubmed-article:11146898 | pubmed:author | pubmed-author:MatsukawaYY | lld:pubmed |
| pubmed-article:11146898 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11146898 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11146898 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11146898 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11146898 | pubmed:pagination | 17-9 | lld:pubmed |
| pubmed-article:11146898 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11146898 | pubmed:meshHeading | pubmed-meshheading:11146898... | lld:pubmed |
| pubmed-article:11146898 | pubmed:meshHeading | pubmed-meshheading:11146898... | lld:pubmed |
| pubmed-article:11146898 | pubmed:meshHeading | pubmed-meshheading:11146898... | lld:pubmed |
| pubmed-article:11146898 | pubmed:meshHeading | pubmed-meshheading:11146898... | lld:pubmed |
| pubmed-article:11146898 | pubmed:meshHeading | pubmed-meshheading:11146898... | lld:pubmed |
| pubmed-article:11146898 | pubmed:meshHeading | pubmed-meshheading:11146898... | lld:pubmed |
| pubmed-article:11146898 | pubmed:meshHeading | pubmed-meshheading:11146898... | lld:pubmed |
| pubmed-article:11146898 | pubmed:meshHeading | pubmed-meshheading:11146898... | lld:pubmed |
| pubmed-article:11146898 | pubmed:meshHeading | pubmed-meshheading:11146898... | lld:pubmed |
| pubmed-article:11146898 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11146898 | pubmed:articleTitle | Serum concentration of interferon-alpha: a comparison between once-a-day and twice-a-day administration. | lld:pubmed |
| pubmed-article:11146898 | pubmed:affiliation | Department of Internal Medicine, Nihon University School of Medicine, Oyaguchi-Kamimachi Itabashi 173-8610, Tokyo, Japan. m-2000@sphere.ne.jp | lld:pubmed |
| pubmed-article:11146898 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11146898 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:11146898 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:11146898 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
