| pubmed-article:11145906 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C0001175 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C0522424 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C1537056 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C0024398 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C0042211 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C1705294 | lld:lifeskim |
| pubmed-article:11145906 | lifeskim:mentions | umls-concept:C0449435 | lld:lifeskim |
| pubmed-article:11145906 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11145906 | pubmed:dateCreated | 2001-1-26 | lld:pubmed |
| pubmed-article:11145906 | pubmed:abstractText | Four rhesus macaques were sequentially immunized with live vaccines DeltavpuDeltanefSHIV-4 (vaccine-I) and Deltavpu SHIV(PPC) (vaccine-II). The vaccine viruses did not replicate productively in the peripheral blood mononuclear cells (PBMCs) of the vaccinated animals. All four animals developed binding antibodies against both the vaccine-I and -II envelope glycoproteins but neutralizing antibodies only against vaccine-I. They developed vaccine virus-specific CTLs that also recognized homologous as well as heterologous pathogenic SHIVs. Thirty weeks after the last immunization, the vaccinated animals and three unvaccinated control animals were challenged iv with a highly virulent heterologous SHIV(89.6)P. As expected, the three unvaccinated control animals developed large numbers of infectious PBMCs, high plasma viremia, and precipitous loss of CD4(+) T cells. Two controls did not develop any immune response and succumbed to AIDS in about 6 months. The third control animal developed neutralizing antibodies and had a more chronic disease course, but eventually succumbed to AIDS-related complications 81 weeks after inoculation. The four vaccinated animals became infected with challenge virus as indicated by the presence of challenge virus-specific DNA in the PBMCs and RNA in plasma. However, virus in these animals replicated approximately 200- to 60,000-fold less efficiently than in control animals and eventually, plasma viral RNA became undetectable in three of the four vaccinates. The animals maintained normal CD4(+) T-cell levels throughout the observation period of 85 weeks after a transient drop at Week 3 postchallenge. They also maintained CTL responses throughout the observation period. These studies thus showed that the graded immunization schedule resulted in a safe and highly effective long-lasting immune response that was associated with protection against AIDS by highly pathogenic heterologous SHIV(89.6)P. | lld:pubmed |
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| pubmed-article:11145906 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11145906 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11145906 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11145906 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11145906 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11145906 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11145906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11145906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11145906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11145906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11145906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11145906 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11145906 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11145906 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11145906 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:KumarAA | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:LimRR | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:MukherjeeSS | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:PiatakMM | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:MASS | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:McClureH MHM | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:NarayanOO | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:JinKK | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:LifsonJ DJD | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:ShefferDD | lld:pubmed |
| pubmed-article:11145906 | pubmed:author | pubmed-author:AdanyII | lld:pubmed |
| pubmed-article:11145906 | pubmed:copyrightInfo | Copyright 2001 Academic Press. | lld:pubmed |
| pubmed-article:11145906 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11145906 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:11145906 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:11145906 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11145906 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11145906 | pubmed:pagination | 241-56 | lld:pubmed |
| pubmed-article:11145906 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11145906 | pubmed:meshHeading | pubmed-meshheading:11145906... | lld:pubmed |
| pubmed-article:11145906 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11145906 | pubmed:articleTitle | Sequential immunization of macaques with two differentially attenuated vaccines induced long-term virus-specific immune responses and conferred protection against AIDS caused by heterologous simian human immunodeficiency Virus (SHIV(89.6)P). | lld:pubmed |
| pubmed-article:11145906 | pubmed:affiliation | Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA. akumar@kumc.edu | lld:pubmed |
| pubmed-article:11145906 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11145906 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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