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pubmed-article:11127265pubmed:abstractTextMorphological criteria to distinguish between reactive and neoplastic B cell lymphocytoid infiltrates in trephines have been defined but are not always reliable. Polymerase chain reaction (PCR) analysis of the CDR3 region of the immunoglobulin heavy chain (IgH) gene which, by demonstrating monoclonality, can provide additional arguments in favour of lymphoid malignancy is now frequently used for the detection and follow up of B cell lymphoma (NHL). The aim of this study was to investigate the usefulness of morphological findings in bone marrow biopsies in comparison with data obtained by PCR analysis.lld:pubmed
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pubmed-article:11127265pubmed:articleTitleEvaluation of B cell lymphoid infiltrates in bone marrow biopsies by morphology, immunohistochemistry, and molecular analysis.lld:pubmed
pubmed-article:11127265pubmed:affiliationDepartment of Pathology, University Hospital of Leuven, Minderbroedersstraat 12, 3000 Leuven, Belgium. Brigitte.Maes@uz.kuleuven.ac.belld:pubmed
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