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pubmed-article:11125278pubmed:abstractTextSecretion of interleukin-2 (IL-2) and interferon-gamma (IFNgamma) in whole blood cell cultures after phytohemagglutinin (PHA) and pokeweed mitogen (PWM) stimulation was evaluated in 42 small-cell lung cancer patients before treatment. Blood cultures from patients with extensive and limited disease have lower IFNgamma secretions after PWM stimulation and lower IL-2 secretions after PWM and PHA stimulation, but this was not statistically significant. IFNgamma but not IL-2 secretion was significantly higher after PWM stimulation in cultures from patients with better clinical performance status (0 + 1, WHO scale). Blood cultures from patients with tumor regression after treatment had a higher secretion of IFNgamma after PWM stimulation. In contrast, blood cultures from patients with a poor prognosis had significantly lower IL-2 and IFNgamma secretions after stimulation with PWM, and a lower IL-2 secretion after stimulation with PHA.lld:pubmed
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pubmed-article:11125278pubmed:authorpubmed-author:RogalaEElld:pubmed
pubmed-article:11125278pubmed:authorpubmed-author:von KleistSSlld:pubmed
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pubmed-article:11125278pubmed:authorpubmed-author:PanorskaAAlld:pubmed
pubmed-article:11125278pubmed:copyrightInfoCopyright 2001 S. Karger AG, Basellld:pubmed
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pubmed-article:11125278pubmed:volume22lld:pubmed
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pubmed-article:11125278pubmed:pagination72-6lld:pubmed
pubmed-article:11125278pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:11125278pubmed:articleTitleInterferon gamma and interleukin-2 secretion in whole blood cell cultures from small-cell lung cancer patients.lld:pubmed
pubmed-article:11125278pubmed:affiliationNational Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland. j.szopinski@igichp.edulld:pubmed
pubmed-article:11125278pubmed:publicationTypeJournal Articlelld:pubmed