| pubmed-article:11122240 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11122240 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:11122240 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:11122240 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11122240 | lifeskim:mentions | umls-concept:C0041327 | lld:lifeskim |
| pubmed-article:11122240 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:11122240 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:11122240 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:11122240 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11122240 | pubmed:dateCreated | 2000-12-26 | lld:pubmed |
| pubmed-article:11122240 | pubmed:abstractText | Immune parameters were compared in four groups of Ugandan subjects: HIV-and HIV+ adult patients with active pulmonary TB (HIV- PTB n = 38; HIV+ PTB n = 28), patients with HIV infection only (n = 26) and PPD+ healthy controls (n = 25). Compared with healthy controls, CD4 and CD8 T cells from patients with HIV and/or PTB expressed more activation markers (HLA-DR, CD38); their CD8 T cells expressed more CD95 (pre-apoptosis) and less CD28 (co-stimulatory receptor). Peripheral blood mononuclear cells (PBMC) of patients with either HIV or PTB were impaired in interferon-gamma (IFN-gamma) production upon antigenic stimulation. PTB (with or without HIV) was characterized by monocytosis, granulocytosis, increased transforming growth factor-beta 1 production and PPD-induced apoptosis. In vivo CD4 T cell depletion, in vitro increased spontaneous CD4 T cell apoptosis and defects in IFN-gamma responses upon mitogenic stimulation were restricted to HIV+ subjects (with or without PTB). Overlapping and distinctive immune alterations, associated with PTB and HIV, might explain mutual unfavourable influences of both diseases. | lld:pubmed |
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| pubmed-article:11122240 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11122240 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11122240 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11122240 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11122240 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11122240 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:JohnsonJJ | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:AzizM AMA | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:EllnerJJ | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:HirschCC | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:ColebundersRR | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:VanhamGG | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:ToossiZZ | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:OkweraAA | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:MugerwaRR | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:MugyenyiPP | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:HertogheTT | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:WajjaAA | lld:pubmed |
| pubmed-article:11122240 | pubmed:author | pubmed-author:NtambiLL | lld:pubmed |
| pubmed-article:11122240 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11122240 | pubmed:volume | 122 | lld:pubmed |
| pubmed-article:11122240 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11122240 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11122240 | pubmed:pagination | 350-7 | lld:pubmed |
| pubmed-article:11122240 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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