Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:11120752rdf:typepubmed:Citationlld:pubmed
pubmed-article:11120752lifeskim:mentionsumls-concept:C0011053lld:lifeskim
pubmed-article:11120752lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:11120752lifeskim:mentionsumls-concept:C0017155lld:lifeskim
pubmed-article:11120752lifeskim:mentionsumls-concept:C0015127lld:lifeskim
pubmed-article:11120752lifeskim:mentionsumls-concept:C0017337lld:lifeskim
pubmed-article:11120752lifeskim:mentionsumls-concept:C1314792lld:lifeskim
pubmed-article:11120752lifeskim:mentionsumls-concept:C1416612lld:lifeskim
pubmed-article:11120752lifeskim:mentionsumls-concept:C0599894lld:lifeskim
pubmed-article:11120752lifeskim:mentionsumls-concept:C1521840lld:lifeskim
pubmed-article:11120752lifeskim:mentionsumls-concept:C0332453lld:lifeskim
pubmed-article:11120752pubmed:issue12lld:pubmed
pubmed-article:11120752pubmed:dateCreated2001-1-22lld:pubmed
pubmed-article:11120752pubmed:abstractTextThe KvLQT1 gene encodes a voltage-gated potassium channel. Mutations in KvLQT1 underlie the dominantly transmitted Ward-Romano long QT syndrome, which causes cardiac arrhythmia, and the recessively transmitted Jervell and Lange-Nielsen syndrome, which causes both cardiac arrhythmia and congenital deafness. KvLQT1 is also disrupted by balanced germline chromosomal rearrangements in patients with Beckwith-Wiedemann syndrome (BWS), which causes prenatal overgrowth and cancer. Because of the diverse human disorders and organ systems affected by this gene, we developed an animal model by inactivating the murine Kvlqt1. No electrocardiographic abnormalities were observed. However, homozygous mice exhibited complete deafness, as well as circular movement and repetitive falling, suggesting imbalance. Histochemical study revealed severe anatomic disruption of the cochlear and vestibular end organs, suggesting that Kvlqt1 is essential for normal development of the inner ear. Surprisingly, homozygous mice also displayed threefold enlargement by weight of the stomach resulting from mucous neck cell hyperplasia. Finally, there were no features of BWS, suggesting that Kvlqt1 is not responsible for BWS.lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:languageenglld:pubmed
pubmed-article:11120752pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:citationSubsetAIMlld:pubmed
pubmed-article:11120752pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11120752pubmed:statusMEDLINElld:pubmed
pubmed-article:11120752pubmed:monthDeclld:pubmed
pubmed-article:11120752pubmed:issn0021-9738lld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:FrancisHHlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:FOYJ LJLlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:FeinbergA PAPlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:CoffeyR JRJlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:LeeM PMPlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:GoldenringJ...lld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:LustigL RLRlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:HoR DRDlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:BuntonT ETElld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:TomaselloAAlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:WashingtonKKlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:BergerR DRDlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:ArganiPPlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:LimbCClld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:RavenelJ DJDlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:BrandenburgS...lld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:LitziT JTJlld:pubmed
pubmed-article:11120752pubmed:authorpubmed-author:GorelikowMMlld:pubmed
pubmed-article:11120752pubmed:issnTypePrintlld:pubmed
pubmed-article:11120752pubmed:volume106lld:pubmed
pubmed-article:11120752pubmed:ownerNLMlld:pubmed
pubmed-article:11120752pubmed:authorsCompleteYlld:pubmed
pubmed-article:11120752pubmed:pagination1447-55lld:pubmed
pubmed-article:11120752pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
pubmed-article:11120752pubmed:meshHeadingpubmed-meshheading:11120752...lld:pubmed
More...