| pubmed-article:11119576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11119576 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:11119576 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:11119576 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11119576 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:11119576 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11119576 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:11119576 | lifeskim:mentions | umls-concept:C1511572 | lld:lifeskim |
| pubmed-article:11119576 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11119576 | pubmed:dateCreated | 2001-1-4 | lld:pubmed |
| pubmed-article:11119576 | pubmed:abstractText | Newborns are very susceptible to infections because their immune systems are not fully developed and react to antigen exposure preferentially with unresponsiveness. UV-inactivated herpes simplex virus type 1 (HSV-1) represents such an antigen and does not induce an immune response in neonates. In contrast, protective T cells were primed in newborn mice by a single replicative cycle of DISC HSV-1 given once within 24 h of birth. Each of the HSV-1-primed CD4(+) or CD8(+) T cells induced in wild-type or interferon-deficient mice conferred resistance to naive animals exposed to a lethal virus challenge. Inactivated HSV-1, injected at variable doses up to 10(4) times that of DISC HSV-1, was ineffective in inducing any detectable immune responses in neonates. Thus, the capacity of HSV-1 to replicate once, but not the number of virus particles per se, was decisive in inducing protective T-cell-associated immunity in newborn mice. | lld:pubmed |
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| pubmed-article:11119576 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11119576 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11119576 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11119576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11119576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11119576 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11119576 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:11119576 | pubmed:author | pubmed-author:FranchiniMM | lld:pubmed |
| pubmed-article:11119576 | pubmed:author | pubmed-author:SuterMM | lld:pubmed |
| pubmed-article:11119576 | pubmed:author | pubmed-author:AckermannMM | lld:pubmed |
| pubmed-article:11119576 | pubmed:author | pubmed-author:SchwerdelCC | lld:pubmed |
| pubmed-article:11119576 | pubmed:author | pubmed-author:RuedlCC | lld:pubmed |
| pubmed-article:11119576 | pubmed:author | pubmed-author:AbrilCC | lld:pubmed |
| pubmed-article:11119576 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11119576 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:11119576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11119576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11119576 | pubmed:pagination | 83-9 | lld:pubmed |
| pubmed-article:11119576 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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