| pubmed-article:11115418 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11115418 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:11115418 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11115418 | lifeskim:mentions | umls-concept:C0003842 | lld:lifeskim |
| pubmed-article:11115418 | lifeskim:mentions | umls-concept:C0025474 | lld:lifeskim |
| pubmed-article:11115418 | lifeskim:mentions | umls-concept:C0042401 | lld:lifeskim |
| pubmed-article:11115418 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:11115418 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:11115418 | lifeskim:mentions | umls-concept:C2709063 | lld:lifeskim |
| pubmed-article:11115418 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11115418 | pubmed:dateCreated | 2001-1-26 | lld:pubmed |
| pubmed-article:11115418 | pubmed:abstractText | Resveratrol has been shown to induce vasorelaxation. In this study, we investigated the mechanism(s) of resveratrol-induced vasorelaxation in resistance mesenteric arteries from male lean and dietary-induced obese rats. Compared with lean rats, arteries from dietary-obese rats showed significant (P<0.001) endothelial dysfunction, as indicated by a decrease (>20%) in maximal acetylcholine-induced vasorelaxation. Resveratrol (5-35 micromol/l) induced concentration-dependent relaxation of mesenteric arteries preconstricted with noradrenaline (8 micromol/l) or KCl (125 mmol/l) from both lean and dietary-obese rats. There were no significant differences between the two groups, achieving a maximum relaxation of >95% at a concentration of 35 micromol/l. In noradrenaline-preconstricted arteries from lean rats, N(G)-nitro-L-arginine methyl ester (L-NAME; 100 and 300 micromol/l) caused a significant (P<0.01) concentration-dependent rightward shift in reseveratrol activity, with no effect on maximal responses. However, L-NAME (100 and 300 micromol/l) did not alter the effects of reseveratrol on arteries from dietary-obese rats, giving superimposed concentration-responses curves. Indomethacin was also ineffective in altering resveratrol activity in arteries from both lean and dietary-obese rats. In noradrenaline-precontracted arteries from dietary-obese rats, responses to resveratrol were not attenuated by endothelial denudation, indicating an action independent of the endothelium. This study indicates that: (a) the maximal effects of resveratrol on resistance arteries from lean and dietary-obese rats are not effected by endothelial dysfunction, and (b) the effects of resveratrol in lean animals (where endothelial function is not impaired), but not in dietary-obese rats, are mediated via NO. | lld:pubmed |
| pubmed-article:11115418 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11115418 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115418 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11115418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11115418 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11115418 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11115418 | pubmed:issn | 0143-5221 | lld:pubmed |
| pubmed-article:11115418 | pubmed:author | pubmed-author:WilliamsGG | lld:pubmed |
| pubmed-article:11115418 | pubmed:author | pubmed-author:SmithS LSL | lld:pubmed |
| pubmed-article:11115418 | pubmed:author | pubmed-author:DoyleP JPJ | lld:pubmed |
| pubmed-article:11115418 | pubmed:author | pubmed-author:NaderaliE KEK | lld:pubmed |
| pubmed-article:11115418 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11115418 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:11115418 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11115418 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11115418 | pubmed:pagination | 55-60 | lld:pubmed |
| pubmed-article:11115418 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11115418 | pubmed:meshHeading | pubmed-meshheading:11115418... | lld:pubmed |
| pubmed-article:11115418 | pubmed:meshHeading | pubmed-meshheading:11115418... | lld:pubmed |
| pubmed-article:11115418 | pubmed:meshHeading | pubmed-meshheading:11115418... | lld:pubmed |
| pubmed-article:11115418 | pubmed:meshHeading | pubmed-meshheading:11115418... | lld:pubmed |
| pubmed-article:11115418 | pubmed:meshHeading | pubmed-meshheading:11115418... | lld:pubmed |
| pubmed-article:11115418 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11115418 | pubmed:articleTitle | The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats. | lld:pubmed |
| pubmed-article:11115418 | pubmed:affiliation | Diabetes and Endocrinology Research Unit, Department of Medicine, University of Liverpool, UCD, Daulby Street, Liverpool L69 3GA, UK. naderali@liverpool.ac.uk | lld:pubmed |
| pubmed-article:11115418 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11115418 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11115418 | lld:pubmed |
