| pubmed-article:11112403 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11112403 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11112403 | lifeskim:mentions | umls-concept:C0162783 | lld:lifeskim |
| pubmed-article:11112403 | lifeskim:mentions | umls-concept:C0237753 | lld:lifeskim |
| pubmed-article:11112403 | lifeskim:mentions | umls-concept:C0439605 | lld:lifeskim |
| pubmed-article:11112403 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:11112403 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:11112403 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:11112403 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11112403 | pubmed:dateCreated | 2001-2-2 | lld:pubmed |
| pubmed-article:11112403 | pubmed:abstractText | Random number generation (RNG) engages a number of executive processes. We used positron emission tomography (PET) to measure regional cerebral blood flow (rCBF) in six volunteers who performed RNG and a control counting (COUNT) task at six rates paced by a tone. This provided a systematic variation of difficulty of RNG. Relative to COUNT, RNG was associated with significant activation of the left dorsolateral prefrontal cortex (DLPFC), the anterior cingulate, the superior parietal cortex bilaterally, the right inferior frontal cortex, and the left and right cerebellar hemispheres. Faster rates of RNG were associated with a significant decrease in regional cerebral blood flow (rCBF) in the left and right DLPFC and the right superior parietal cortex. rCBF in the left DLPFC was significantly and negatively associated with count score 1, a measure of habitual counting during RNG. These results are discussed in relation to the network modulation model of RNG developed on the basis of our previous studies using transcranial magnetic stimulation and dual task paradigms. This suggests that during RNG, suppression of habitual counting is achieved through the modulatory (inhibitory) influence of the left DLPFC over a number associative network distributed in the superior temporal cortex. At faster rates of RNG the synchronization demands of paced RNG result in the breakdown of this modulatory influence, which is evident from decreased rCBF in the left DLPFC and increased habitual counting at faster rates. | lld:pubmed |
| pubmed-article:11112403 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11112403 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11112403 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11112403 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11112403 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11112403 | pubmed:issn | 1053-8119 | lld:pubmed |
| pubmed-article:11112403 | pubmed:author | pubmed-author:FullerRR | lld:pubmed |
| pubmed-article:11112403 | pubmed:author | pubmed-author:FrithC DCD | lld:pubmed |
| pubmed-article:11112403 | pubmed:author | pubmed-author:JahanshahiMM | lld:pubmed |
| pubmed-article:11112403 | pubmed:author | pubmed-author:DirnbergerGG | lld:pubmed |
| pubmed-article:11112403 | pubmed:copyrightInfo | Copyright 2000 Academic Press. | lld:pubmed |
| pubmed-article:11112403 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11112403 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:11112403 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11112403 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11112403 | pubmed:pagination | 713-25 | lld:pubmed |
| pubmed-article:11112403 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
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| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:meshHeading | pubmed-meshheading:11112403... | lld:pubmed |
| pubmed-article:11112403 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11112403 | pubmed:articleTitle | The role of the dorsolateral prefrontal cortex in random number generation: a study with positron emission tomography. | lld:pubmed |
| pubmed-article:11112403 | pubmed:affiliation | Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom. | lld:pubmed |
| pubmed-article:11112403 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11112403 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11112403 | lld:pubmed |
