| pubmed-article:11112136 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11112136 | lifeskim:mentions | umls-concept:C0004096 | lld:lifeskim |
| pubmed-article:11112136 | lifeskim:mentions | umls-concept:C0041427 | lld:lifeskim |
| pubmed-article:11112136 | lifeskim:mentions | umls-concept:C0392707 | lld:lifeskim |
| pubmed-article:11112136 | lifeskim:mentions | umls-concept:C0085129 | lld:lifeskim |
| pubmed-article:11112136 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:11112136 | lifeskim:mentions | umls-concept:C1328885 | lld:lifeskim |
| pubmed-article:11112136 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:11112136 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11112136 | pubmed:dateCreated | 2001-1-24 | lld:pubmed |
| pubmed-article:11112136 | pubmed:abstractText | We measured asthma in the last 12 mo, diagnosed by a respiratory physician at interview; atopy, defined by a positive skin prick test to any of eight common allergens; and bronchial hyperresponsiveness (BHR) to hypertonic saline, in 381 twin pairs aged 8 to 18 yr selected from the Australian Twin Registry-183 monozygous (MZ) and 198 dizygous (DZ). The associations between twins, as measured by an odds ratio, were greater in MZ pairs compared with DZ pairs for asthma: 25.6 (95% confidence interval 11.3- 57.8) versus 1.9 (1.0-3. 5); atopy: 14.6 (7.1-30.1) versus 2.5 (1.4- 4.5); and BHR: 14.1 (6. 4-31.0) versus 4.2 (2.1-8.6) (all p < 0.002). The associations between each pair of traits within an individual were slightly greater than the association between one trait in a twin and the other trait in the cotwin (cross-trait cross-pair) in MZ pairs. Further, the associations in MZ pairs were greater than in DZ pairs (p < 0.05). Under the assumptions of the classic twin model, these data suggest that the strong cross-sectional associations between these three traits are due to an overlap between the genetic factors involved in each of these three traits. | lld:pubmed |
| pubmed-article:11112136 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11112136 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11112136 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11112136 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11112136 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11112136 | pubmed:issn | 1073-449X | lld:pubmed |
| pubmed-article:11112136 | pubmed:author | pubmed-author:RobertsonC... | lld:pubmed |
| pubmed-article:11112136 | pubmed:author | pubmed-author:ClarkeJ RJR | lld:pubmed |
| pubmed-article:11112136 | pubmed:author | pubmed-author:HopperJ LJL | lld:pubmed |
| pubmed-article:11112136 | pubmed:author | pubmed-author:ClaytonD GDG | lld:pubmed |
| pubmed-article:11112136 | pubmed:author | pubmed-author:JenkinsM AMA | lld:pubmed |
| pubmed-article:11112136 | pubmed:author | pubmed-author:CarlinJ BJB | lld:pubmed |
| pubmed-article:11112136 | pubmed:author | pubmed-author:MayneCC | lld:pubmed |
| pubmed-article:11112136 | pubmed:author | pubmed-author:DaltonM FMF | lld:pubmed |
| pubmed-article:11112136 | pubmed:author | pubmed-author:HolstD PDP | lld:pubmed |
| pubmed-article:11112136 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11112136 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:11112136 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11112136 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11112136 | pubmed:pagination | 2188-93 | lld:pubmed |
| pubmed-article:11112136 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:meshHeading | pubmed-meshheading:11112136... | lld:pubmed |
| pubmed-article:11112136 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11112136 | pubmed:articleTitle | Evidence for genetic associations between asthma, atopy, and bronchial hyperresponsiveness: a study of 8- to 18-yr-old twins. | lld:pubmed |
| pubmed-article:11112136 | pubmed:affiliation | Respiratory & Cystic Fibrosis Unit, The Birmingham Children's Hospital NHS Trust, Birmingham, United Kingdom. | lld:pubmed |
| pubmed-article:11112136 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11112136 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11112136 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:11112136 | pubmed:publicationType | Twin Study | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11112136 | lld:pubmed |
